ReviewAnnals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc2017
Beat-to-beat ECG restitution: A review and proposal for a new biomarker to assess cardiac stress and ventricular tachyarrhythmia vulnerability.
Review in Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Detection of exercising ectopic atrial and ventricular beats using non-linear analysis of clinically normal racehorse electrocardiograms at rest or low-intensity exercise.Scientific reports · 2026Article
- The electrical restitution of the non-propagated cardiac ventricular action potential.Pflugers Archiv : European journal of physiology · 2024Review
- Dynamic detection and reversal of myocardial ischemia using an artificially intelligent bioelectronic medicine.Science advances · 2022Article
- Sex and Rate Change Differences in QT/RR Hysteresis in Healthy Subjects.Frontiers in physiology · 2021Article
- ECG Restitution Analysis and Machine Learning to Detect Paroxysmal Atrial Fibrillation: Insight from the Equine Athlete as a Model for Human Athletes.Function (Oxford, England) · 2021Article
- A preliminary report about the detection of ventricular repolarisation in patients with non-alcoholic fatty liver disease.Journal of Taibah University Medical Sciences · 2020Article
- Identification of Drug-Induced Multichannel Block and Proarrhythmic Risk in Humans Using Continuous T Vector Velocity Effect Profiles Derived From Surface Electrocardiograms.Frontiers in physiology · 2020Article
- Restitution and Stability of Human Ventricular Action Potential at High and Variable Pacing Rate.Biophysical journal · 2019Article
- QT Assessment in Early Drug Development: The Long and the Short of It.International journal of molecular sciences · 2019Review
- The application of Lempel-Ziv and Titchener complexity analysis for equine telemetric electrocardiographic recordings.Scientific reports · 2019Article
- Comparison of Two Highly Automated ECG Algorithms for Detection of Drug-Induced Cardiac Ion Channel Block.Clinical pharmacology and therapeutics · 2018Article
- Importance of QT/RR hysteresis correction in studies of drug-induced QTc interval changes.Journal of pharmacokinetics and pharmacodynamics · 2018Article
- QT Prolongation and Malignant Arrhythmia: How Serious a Problem?European cardiology · 2017Review
- Beat-to-beat ECG restitution: A review and proposal for a new biomarker to assess cardiac stress and ventricular tachyarrhythmia vulnerability.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2017Review
- QT Interval and Cardiac Restitution Ratio Complexity in Standardbred Racehorses From Rest to Maximal Effort: Insights Into Arrhythmia Risk.Journal of veterinary internal medicineArticle
- Population-based beat-to-beat QT analysis from Holter recordings in the long QT syndrome.Journal of electrocardiologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCardiac restitution is the ability of the heart to recover from one beat to the next. Ventricular arrhythmia vulnerability can occur when the heart does not properly adjust to sudden changes in rate or in hemodynamics leading to excessive temporal and/or spatial heterogeneity in conduction or repolarization. Restitution has historically been used to study, by invasive means, the dynamics of the relationship between action potential duration (APD) and diastolic interval (DI) in sedated subjects using various pacing protocols. Even though the analogous measures of APD and DI can be obtained using the surface ECG to acquire the respective QT and TQ intervals for ECG restitution, this methodology has not been widely adopted for a number of reasons.
methodsRecent development of more advanced software algorithms enables ECG intervals to be measured accurately, on a continuous beat-to-beat basis, in an automated manner, and under highly dynamic conditions (i.e., ambulatory or exercise) providing information beyond that available in the typical resting state.
resultsCurrent breakthroughs in ECG technology will allow ECG restitution measures to become a practical approach for providing quantitative measures of the risks for ventricular arrhythmias as well as cardiac stress in general.
conclusionsIn addition to a review of the underlying principles and caveats of ECG restitution, a new approach toward an advancement of more integrated restitution biomarkers is proposed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.