ArticleNature communications2017
A TRIM insertion in the promoter of Ms2 causes male sterility in wheat.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 94 citations in OpenAlex.
- TaRIP2 Positively Regulates Wheat Pollen Wall Formation Through MYB80-Controlled Lipid Metabolism.Plant biotechnology journal · 2026Article
- A Genome-Wide Pseudogene Map Reveals the Asymmetric Evolution of the A, B, and D Subgenomes in Common Wheat.Plants (Basel, Switzerland) · 2026Article
- Characterization and Phylogenomic Implications of the Mitochondrial Genome ofEcology and evolution · 2026Article
- Comparative and phylogenetic study on the chloroplast genomes of CMS with the cytoplasm of Aegilops ovata and its maintainer line in wheat.BMC genomics · 2025Article
- Development of a semi-dwarf dominant genic male sterile wheat with seed red fluorescence as a visible marker.Molecular breeding : new strategies in plant improvement · 2025Article
- A TOPLESS-related gene regulates both male and female sterility in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Natural variation in TaERF-A1 confers semi-dwarf and lodging-resistant plant architecture in wheat.Plant communications · 2025Article
- Microinjection of the CRISPR/Cas9 editing system through the germ pore of a wheat microspore induces mutations in the target Ms2 gene.Molecular biology reports · 2024Article
- Transposable elements cause the loss of self-incompatibility in citrus.Plant biotechnology journal · 2024Article
- An epi-allele of SMS causes Sanming dominant genic male sterility in rice.Science China. Life sciences · 2023Article
- Disruption of the Contents of Endogenous Hormones Cause Pollen Development Obstruction and Abortion in Male-Sterile Hybrid Lily Populations.Plants (Basel, Switzerland) · 2023Article
- Anther-specific expression of OsRIP1 causes dominant male sterility in rice.Plant biotechnology journal · 2023Article
- Spontaneous movement of a retrotransposon generated genic dominant male sterility providing a useful tool for rice breeding.National science review · 2023Article
- Fast integration and accumulation of beneficial breeding alleles through an AB-NAMIC strategy in wheat.Plant communications · 2023Article
- A bifunctional selectable marker for wheat transformation contributes to the characterization of male-sterile phenotype induced by a synthetic Ms2 gene.Plant cell reports · 2023Article
- CRISPR/Cas9-targeted mutagenesis of TaDCL4, TaDCL5 and TaRDR6 induces male sterility in common wheat.Plant biotechnology journal · 2023Article
- High-throughput haploid induction in species with bisexual flowers.Plant communications · 2023Article
- Integrated Analysis of Microarray, Small RNA, and Degradome Datasets Uncovers the Role of MicroRNAs in Temperature-Sensitive Genic Male Sterility in Wheat.International journal of molecular sciences · 2022Article
- Identification of an anther-specific promoter from a male sterile AB line in Chinese cabbage (3 Biotech · 2022Article
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Corrections and comments
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Authors and funding
16 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The male-sterile ms2 mutant has been known for 40 years and has become extremely important in the commercial production of wheat. However, the gene responsible for this phenotype has remained unknown. Here we report the map-based cloning of the Ms2 gene. The Ms2 locus is remarkable in several ways that have implications in basic biology. Beyond having no functional annotation, barely detectable transcription in fertile wild-type wheat plants, and accumulated destructive mutations in Ms2 orthologs, the Ms2 allele in the ms2 mutant has acquired a terminal-repeat retrotransposon in miniature (TRIM) element in its promoter. This TRIM element is responsible for the anther-specific Ms2 activation that confers male sterility. The identification of Ms2 not only unravels the genetic basis of a historically important breeding trait, but also shows an example of how a TRIM element insertion near a gene can contribute to genetic novelty and phenotypic plasticity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.