ArticleIntensive care medicine experimental2017
The role of high airway pressure and dynamic strain on ventilator-induced lung injury in a heterogeneous acute lung injury model.
Article in Intensive care medicine experimental, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 54 citations in OpenAlex.
- Artificial intelligence-assisted multiscale lung modeling to predict alveolar septal wall stress.Acta biomaterialia · 2026Article
- Expert recommendations for setting and adjusting airway pressure release ventilation based on clinical experience and basic science evidence.Frontiers in medicine · 2026Article
- Physics-Informed In-Silico Dynamic Computed Tomography of Human Lungs: Generation, Evaluation, and Refinement.Journal of biomechanical engineering · 2025Article
- Mechanical ventilation energy analysis: Recruitment focuses injurious power in the ventilated lung.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Cyclic mechanical loading of photopolymerized methacrylated hydrogels for probing interdependent effects of strain, stiffness, and substrate composition in pulmonary fibrogenesis.Scientific reports · 2025Article
- Lung recruitment mechanics: coalescing tissue strains with organ expansion.Respiratory research · 2025Article
- Monitoring lung recruitability during recruitment maneuvers in children with respiratory failure on ECMO using electrical impedance tomography: case report.Frontiers in pediatrics · 2025Article
- Computationally-directed mechanical ventilation in a porcine model of ARDS.Frontiers in physiology · 2025Article
- Effects of Lung Injury and Abdominal Insufflation on Respiratory Mechanics and Lung Volume During Time-Controlled Adaptive Ventilation.Respiratory care · 2024Article
- Atelectrauma can be avoided if expiration is sufficiently brief: evidence from inverse modeling and oscillometry during airway pressure release ventilation.Critical care (London, England) · 2024Article
- Article
- Mechanical Power and Ventilator-induced Lung Injury: What Does Physics Have to Say?American journal of respiratory and critical care medicine · 2024Article
- In-silico CT lung phantom generated from finite-element mesh.Proceedings of SPIE--the International Society for Optical Engineering · 2024Article
- Time-Controlled Adaptive Ventilation (TCAV): a personalized strategy for lung protection.Respiratory research · 2024Review
- First Stabilize and then Gradually Recruit: A Paradigm Shift in Protective Mechanical Ventilation for Acute Lung Injury.Journal of clinical medicine · 2023Review
- Protective ventilation in a pig model of acute lung injury: timing is as important as pressure.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Unshrinking the baby lung to calm the VILI vortex.Critical care (London, England) · 2022Review
- Biphasic positive airway pressure spontaneous breathing attenuates lung injury in an animal model of severe acute respiratory distress syndrome.BMC anesthesiology · 2022Article
- Myths and Misconceptions of Airway Pressure Release Ventilation: Getting Past the Noise and on to the Signal.Frontiers in physiology · 2022Review
- RNA-Sequencing approach for exploring the therapeutic effect of umbilical cord mesenchymal stem/stromal cells on lipopolysaccharide-induced acute lung injury.Frontiers in immunology · 2022Article
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAcute respiratory distress syndrome causes a heterogeneous lung injury with normal and acutely injured lung tissue in the same lung. Improperly adjusted mechanical ventilation can exacerbate ARDS causing a secondary ventilator-induced lung injury (VILI). We hypothesized that a peak airway pressure of 40 cmH
methodsPigs were anesthetized, and heterogeneous acute lung injury (ALI) was created by Tween instillation via a bronchoscope to both diaphragmatic lung lobes. Tissue in all other lobes was normal. Airway pressure release ventilation was used to precisely regulate time and pressure at both inspiration and expiration. Animals were separated into two groups: (1) over-distension + high dynamic strain (OD + H
resultsIn normal tissue (N
conclusionsBoth N
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.