ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2019
Assessing time-of-flight signal-to-noise ratio gains within the myocardium and subsequent reductions in administered activity in cardiac PET studies.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
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- EANM procedural guidelines for PET/CT quantitative myocardial perfusion imaging.European journal of nuclear medicine and molecular imaging · 2021Article
- Does time-of-flight improve image quality in the heart?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Understanding the impact of advanced PET reconstruction in cardiac PET: The devil is in the details.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- The effect of time-of-flight and point spread function modeling onJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
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3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTime-of-flight (TOF) is known to increase signal-to-noise ratio (SNR) and facilitate reductions in administered activity. Established measures of SNR gain are derived from areas of uniform uptake, which is not applicable to the heterogeneous uptake in cardiac PET images using fluoro-deoxyglucose (FDG). This study aimed to develop a technique to quantify SNR gains within the myocardium due to TOF.
methodsReference TOF SNR gains were measured in 88 FDG oncology patients. Phantom data were used to translate reference SNR gains and validate a method of quantifying SNR gains within the myocardium from parametric images produced from multiple replicate images. This technique was applied to 13 FDG cardiac viability patients.
resultsReference TOF SNR gains of +23% ± 8.5% were measured in oncology patients. Measurements of SNR gain from the phantom data were in agreement and showed the parametric image technique to be sufficiently robust. SNR gains within the myocardium in the viability patients were +21% ± 2.8%.
conclusionA method to quantify SNR gains from TOF within the myocardium has been developed and evaluated. SNR gains within the myocardium are comparable to those observed by established methods. This allows guidance for protocol optimization for TOF systems in cardiac PET.
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