Observational studyInternational journal of legal medicine2018
Early markers of myocardial ischemia: from the experimental model to forensic pathology cases of sudden cardiac death.
Observational study in International journal of legal medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Immunohistochemical Assessment of Acute Myocardial Infarction: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Postmortem Immunohistochemical Findings in Early Acute Myocardial Infarction: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Time-dependent expression of neural oxidative and inflammatory biomarkers in ischemic stroke using a transient MCAO rat model.Scientific reports · 2025Article
- Ischemic and non-ischemic myocardial injuries at autopsy- an overview for forensic pathologists.International journal of legal medicine · 2025Review
- Sudden Cardiac Death in Pregnant Women-Literature Review and Autopsy Findings.Diagnostics (Basel, Switzerland) · 2025Review
- Is Lung Disease a Risk Factor for Sudden Cardiac Death? A Comparative Case-Control Histopathological Study.Diseases (Basel, Switzerland) · 2025Article
- Forensic significance of intracardiac expressions of Nrf2 in acute myocardial ischemia.Scientific reports · 2024Article
- Differential gene expression patterns in ST-elevation Myocardial Infarction and Non-ST-elevation Myocardial Infarction.Scientific reports · 2024Article
- Endoplasmic reticulum stress-related secretory proteins as biomarkers of early myocardial ischemia-induced sudden cardiac deaths.International journal of legal medicine · 2022Article
- Sudden cardiac death-update.International journal of legal medicine · 2021Review
- Rarely fatal bilateral re-expansion pulmonary edema after inserting a chest tube for unilateral spontaneous pneumothorax: a case report.Forensic science, medicine, and pathology · 2021Article
- The Novel Non-coding Transcriptional Regulator Gm18840 Drives Cardiomyocyte Apoptosis in Myocardial Infarction Post Ischemia/Reperfusion.Frontiers in cell and developmental biology · 2021Article
- Diagnosis of myocardial infarction at autopsy: AECVP reappraisal in the light of the current clinical classification.Virchows Archiv : an international journal of pathology · 2020Review
- Molecular tissue changes in early myocardial ischemia: from pathophysiology to the identification of new diagnostic markers.International journal of legal medicine · 2018Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The goal of this study was to assess whether early markers of myocardial ischemia, identified in a previous experimental work, can be applied in forensic pathology cases of sudden, ischemic cardiac death. These markers include desphosphorylated connexin 43 (Cx43), JunB, TUNEL assay, myoglobin, and troponin T. Fourteen cases of sudden cardiac death with gross and/or histological signs of myocardial infarction and 14 cases of sudden cardiac death with signs of early ischemia at histology and positive immunoreactions for fibronectin and C5b-9 were investigated. The control group was represented by 15 hanging (global hypoxia) cases. Immunohistochemical reactions were classified into four degrees and compared among groups. Cx43 and JunB were significantly more expressed in hanging than in ischemia/infarction, but they showed a different distribution in the tissue (sub-endocardial in ischemia/infarction, diffuse in hanging) and a different intensity of the signal. TUNEL assay was significantly more expressed in the group of early ischemia than in myocardial infarction. Myoglobin and troponin T did not show any significantly different expression among the three groups. Depletion markers have a limited application in forensic cases, and this is mostly because positive (depleted) areas are difficult to distinguish from artifactually paler areas. Nuclear markers (JunB and TUNEL), on the other hand, require a well-trained eye and a high magnification in order to be distinguished. Cx43, JunB, and TUNEL assays were confirmed to be early, sensitive markers for myocardial ischemia. Nonetheless, they are not specific, as they are expressed in global hypoxia as well, but with a different tissular distribution.
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