ArticleEuropean journal of applied physiology2017
Associations of human skeletal muscle fiber type and insulin sensitivity, blood lipids, and vascular hemodynamics in a cohort of premenopausal women.
Article in European journal of applied physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- HIIT'ing or MISS'ing the Optimal Management of Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of High- Versus Moderate-Intensity Exercise Prescription.Frontiers in physiology · 2021Pooled it
- Post-meal exercise under ecological conditions improves post-prandial glucose levels but not 24-hour glucose control.Journal of sports sciences · 2024Trial
- Trial
- Impact of obesity and type 2 diabetes on muscle power, quality, and force-velocity, and their relation to functional capacity.Journal of diabetes and metabolic disorders · 2026Article
- Sexual Dimorphism in the Relationship between Body Composition and Insulin Resistance in Older Adults.Current developments in nutrition · 2026Article
- "Hybrid exercise training improves liver steatosis and inflammation in a randomized trial of sedentary, obese women with non-alcoholic fatty liver disease".BMC sports science, medicine & rehabilitation · 2025Article
- Mediation of fasting blood glucose between relative muscle strength and hypertension: insights from two cohorts.Diabetology & metabolic syndrome · 2025Article
- Fibroblast growth factor 21/extracellular signal-regulated kinase 1/2 pathway as a key link mediates the effects of low-protein diet on skeletal muscle fiber type transformation in pigs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Type IIx muscle fibers are related to poor body composition, glycemic and lipidemic blood profiles in young females: the protective role of type I and IIa muscle fibers.European journal of applied physiology · 2024Article
- Epidemiological, mechanistic, and practical bases for assessment of cardiorespiratory fitness and muscle status in adults in healthcare settings.European journal of applied physiology · 2023Review
- Review
- Body Composition, Fasting Blood Glucose and Lipidemic Indices Are Not Primarily Determined by the Nutritional Intake of Middle-Aged Endurance Trained Men-Another "Athletes' Paradox"?Journal of clinical medicine · 2022Article
- The emerging role of skeletal muscle as a modulator of lipid profile the role of exercise and nutrition.Lipids in health and disease · 2022Article
- Mitochondrial Phenotype as a Driver of the Racial Dichotomy in Obesity and Insulin Resistance.Biomedicines · 2022Review
- Sex Differences in Endurance Running.Sports medicine (Auckland, N.Z.) · 2022Review
- The MOTS-c K14Q polymorphism in the mtDNA is associated with muscle fiber composition and muscular performance.Biochimica et biophysica acta. General subjects · 2022Article
- Role of mitochondria-associated endoplasmic reticulum membranes in insulin sensitivity, energy metabolism, and contraction of skeletal muscle.Frontiers in molecular biosciences · 2022Review
- Genomics and transcriptomics landscapes associated to changes in insulin sensitivity in response to endurance exercise training.Scientific reports · 2021Article
- Aging, obesity, sarcopenia and the effect of diet and exercise intervention.Experimental gerontology · 2021 · on this mapReview
- Sex and race contribute to variation in mitochondrial function and insulin sensitivity.Physiological reports · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
purposeCardiometabolic disease remains a leading cause of morbidity and mortality in developed nations. Consequently, identifying and understanding factors associated with underlying pathophysiological processes leading to chronic cardio metabolic conditions is critical. Metabolic health, arterial elasticity, and insulin sensitivity (SI) may impact disease risk, and may be determined in part by myofiber type. Therefore, the purpose of this study was to test the hypothesis that type I myofiber composition would be associated with high SI, greater arterial elasticity, lower blood pressure, and blood lipids; whereas, type IIx myofibers would be associated with lower SI, lower arterial elasticity, higher blood pressure, blood lipids.
methodsMuscle biopsies were performed on the vastus lateralis in 16 subjects (BMI = 27.62 ± 4.71 kg/m
resultsThe percentage of type I myofibers positively correlated with SI and negatively correlated with systolic blood pressure SBP, diastolic blood pressure, and mean arterial pressure (MAP); whereas, the percentage of type IIx myofibers were negatively correlated with SI and large artery elasticity, and positively correlated with LDL cholesterol, SBP, and MAP.
conclusionsThese data demonstrate a potential link between myofiber composition and cardiometabolic health outcomes in a cohort of premenopausal women. Future research is needed to determine the precise mechanisms in which myofiber composition impacts the pathophysiology of impaired glucose and lipid metabolism, as well as vascular dysfunction.
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