ArticleMolecular and cellular biochemistry2017
IGF2BP1: a novel binding protein of p38 MAPK.
Article in Molecular and cellular biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
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- The induction effect of hydroxyurea and metformin on fetal globin in the K562 cell line.Molecular medicine (Cambridge, Mass.) · 2025Article
- Anillin contributes to prostate cancer progression through the regulation of IGF2BP1 to promote c-Myc and MAPK signaling.American journal of cancer research · 2024Article
- P38 Mitogen-Activated Protein Kinase Protects Against Retinoblastoma Through Regulating USP22/SIRT1/SOST Axis.Frontiers in oncology · 2022Article
- LncRNA LINC00689 Promotes the Tumorigenesis of Glioma via Mediation of miR-526b-3p/IGF2BP1 Axis.Neuromolecular medicine · 2021Article
- PADI2-Catalyzed MEK1 Citrullination Activates ERK1/2 and Promotes IGF2BP1-Mediated SOX2 mRNA Stability in Endometrial Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Transcriptome-wide profiles of circular RNA and RNA-binding protein interactions reveal effects on circular RNA biogenesis and cancer pathway expression.Genome medicine · 2020Article
- METTL3 potentiates resistance to cisplatin through mJournal of cellular and molecular medicine · 2020Article
- mTOR-autophagy promotes pulmonary senescence through IMP1 in chronic toxicity of methamphetamine.Journal of cellular and molecular medicine · 2020Article
- A large cohort study identifying a novel prognosis prediction model for lung adenocarcinoma through machine learning strategies.BMC cancer · 2019Article
- Targeting insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in metastatic melanoma to increase efficacy of BRAFMolecular carcinogenesis · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Signal transduction pathways control various biological processes in cells leading to distinct cellular functions. Protein-protein interactions and post-translational modifications are the physiological events that occur in signaling pathway. p38 MAPK are known to be involved in regulating wide range of cellular processes by interacting and activating relevant signaling molecules by means of phosphorylation. Deregulation of p38 MAPK is associated with various pathological conditions. In order to get an insight into the role played by p38 MAPK in cellular signaling, studies were carried out to identify proteins that interact with p38 MAPK. Mass spectrometry was used to identify the proteins present in p38 MAPK complex obtained by co-immunoprecipitation. Based on mass spectrometry data, here we report insulin-like growth factor-II binding protein 1 (IGF2BP1) as a novel interacting partner of p38 MAPK. IGF2BP1 is a RNA-binding protein predominantly known to be involved in tumor progression. To reconfirm the mass spectrometry data, in silico analysis was carried out. Based on different models predicted in silico, we report the possible interaction domains of p38MAPK and IGF2BP1. Considering the involvement of p38MAPK and IGF2BP1 in cancer, our study opens up the possibility of p38MAPK regulating IGF2BP1 function, and the possibility of targeting this novel interaction for developing cancer-treating drugs is discussed.
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