Evidence map›Paper›PMID 28497350›Full record

ReviewSeminars in immunopathology2017

Synovial cellular and molecular markers in rheumatoid arthritis.

M Asif Amin, David A Fox, Jeffrey H Ruth

Abstract readReview
In one paragraph

Review in Seminars in immunopathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 109 citations in OpenAlex.

  1. Trial
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  3. Review
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  9. Review
  10. Review
  11. ElevatedJournal of inflammation research · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Ferroptosis in Arthritis: Driver of the Disease or Therapeutic Option?International journal of molecular sciences · 2024
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

M Asif AminDivision of Rheumatology and the Clinical Autoimmunity Center of Excellence, University of Michigan, Ann Arbor, MI, USA.
David A FoxDivision of Rheumatology and the Clinical Autoimmunity Center of Excellence, University of Michigan, Ann Arbor, MI, USA. dfox@med.umich.edu.
Jeffrey H RuthDivision of Rheumatology and the Clinical Autoimmunity Center of Excellence, University of Michigan, Ann Arbor, MI, USA.
University of Michigan–Ann Arbor · US

Funding

University of Michigan Clinical Autoimmunity Center of ExcellenceUM1AI144298 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FOX, DAVID ALAN, KHANNA, DINESH · 2019 to 2023
$546k
University of Michigan Autoimmunity Center of Excellence, Clinical Research ProgrUM1AI110557 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FOX, DAVID ALAN · 2014 to 2018
$543k
NIAID NIH HHS UM1 AI110557
6 · The paper itself

Abstract

The profound alterations in the structure, cellular composition, and function of synovial tissue in rheumatoid arthritis (RA) are the basis for the persistent inflammation and cumulative joint destruction that are hallmarks of this disease. In RA, the synovium develops characteristics of a tertiary lymphoid organ, with extensive infiltration of lymphocytes and myeloid cells. Concurrently, the fibroblast-like synoviocytes undergo massive hyperplasia and acquire a tissue-invasive phenotype. In this review, we summarize key components of these processes, focusing on recently-described roles of selected molecular markers of these cellular components of RA synovitis.

Indexed as

BiomarkersAnimalsAntirheumatic AgentsArthritis, RheumatoidCell CommunicationGene Expression RegulationHumansJoint CapsuleMolecular Targeted TherapySignal TransductionSynovial MembraneAntirheumatic AgentsBiomarkers

Identifiers

PMID28497350
PMCPMC5521018
OpenAlexW2614066547

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.