ArticleJournal of natural medicines2017
Triterpenoid saponins from Polaskia chichipe Backbg. and their inhibitory or promotional effects on the melanogenesis of B16 melanoma cells.
Article in Journal of natural medicines, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 6 citations in OpenAlex.
- Skin-Protective Activities ofAntioxidants (Basel, Switzerland) · 2026Article
- Saponins from cactus and their inhibitory effects on amyloid β aggregation.Journal of natural medicines · 2026Article
- Amyloid-β aggregation inhibitory activity of triterpene saponins from the cactus Stenocereus gummosus.Journal of natural medicines · 2025Article
- Saponins Effect on Human Insulin Amyloid Aggregation.Biomolecules · 2024Article
- Molecular Analysis of the Melanogenesis Inhibitory Effect of Saponins-Rich Fraction ofMolecules (Basel, Switzerland) · 2022Article
- Amyloid β aggregation inhibitory activity of triterpene saponins from the cactus Stenocereus pruinosus.Journal of natural medicines · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Five new oleanane-type saponins 1-5 together with a known saponin 6 and a steroidal glycoside 7 were isolated from Polaskia chichipe Backbg., and their structures were determined from their 1D and 2D NMR and HRFABMS spectral data. The six isolated saponins 1-6 were tested for their effects on the melanogenesis of B16 melanoma 4A5 cells. Compound 1 exerted an inhibitory effect at 100 μM whereas compound 3 promoted melanogenesis at the same concentration, even though these two compounds contain the same aglycon structure. The dose-dependent activities of compounds 1 and 3 on melanin synthesis were investigated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.