ReviewPflugers Archiv : European journal of physiology2017
Endocytic receptor LRP2/megalin-of holoprosencephaly and renal Fanconi syndrome.
Review in Pflugers Archiv : European journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 52 citations in OpenAlex.
- Receptor-mediated endocytosis by Megalin: Exploring its role in ligand interaction and disease mechanisms.Genes & diseases · 2026Review
- Article
- SCNT: an R package for data analysis and visualization of single-cell and spatial transcriptomics.BMC bioinformatics · 2025Article
- Circulating Glutathione Peroxidase-3 in Elderly-Association with Renal Function, Cardiovascular Mortality, and Impact of Selenium and Coenzyme QAntioxidants (Basel, Switzerland) · 2024Article
- LRP2 contributes to planar cell polarity-dependent coordination of motile cilia function.Cell and tissue research · 2023Article
- Article
- Effect of nicotine on cholesterol gallstone formation in C57BL/6J mice fed on a lithogenic diet.Experimental and therapeutic medicine · 2023Article
- Article
- Assessment of endocytic traffic and Ocrl function in the developing zebrafish neuroepithelium.Journal of cell science · 2022Article
- Expanding the phenotypic spectrum of mutations in LRP2: a novel candidate gene of non-syndromic familial comitant strabismus.Journal of translational medicine · 2021Article
- The Aging Kidney-As Influenced by Heavy Metal Exposure and Selenium Supplementation.Biomolecules · 2021Review
- LRP2 controls sonic hedgehog-dependent differentiation of cardiac progenitor cells during outflow tract formation.Human molecular genetics · 2020Article
- Article
- Protective Role of Vitamin D in Renal Tubulopathies.Metabolites · 2020Review
- Megalin: a Novel Determinant of Renin-Angiotensin System Activity in the Kidney?Current hypertension reports · 2020Review
- Megalin: A bridge connecting kidney, the renin-angiotensin system, and atherosclerosis.Pharmacological research · 2020Review
- Vitamin D Binding Protein: A Historic Overview.Frontiers in endocrinology · 2019Review
- The Benefits of Tubular Proteinuria: An Evolutionary Perspective.Journal of the American Society of Nephrology : JASN · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Megalin (or LRP2) is an endocytic receptor that plays a central role in embryonic development and adult tissue homeostasis. Loss of this receptor in congenital or acquired diseases results in multiple organ dysfunctions, including forebrain malformation (holoprosencephaly) and renal reabsorption defects (renal Fanconi syndrome). Here, we describe current concepts of the mode of receptor action that include co-receptors and a repertoire of different ligands, and we discuss how these interactions govern functional integrity of the kidney and the brain, and cause disease when defective.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.