Evidence map›Paper›PMID 28497213›Full record

ReviewCurrent osteoporosis reports2017

Bone Pain and Muscle Weakness in Cancer Patients.

Daniel P Milgrom, Neha L Lad, Leonidas G Koniaris, Teresa A Zimmers

Open access · greenAbstract readReview
In one paragraph

Review in Current osteoporosis reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Management of cancer pain due to bone metastasis.Journal of bone and mineral metabolism · 2023
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Protocol for the Pilot Study of Group Video Yogic Breathing App in Breast Cancer Survivors.International journal of AAYUSH and traditional medicine · 2022
    Article
  12. Review
  13. Review
  14. Article
  15. Optimization andFrontiers in pharmacology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Daniel P MilgromDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Neha L LadDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Leonidas G KoniarisDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Teresa A ZimmersDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN, 46202, USA. zimmerst@iu.edu.
Indiana University – Purdue University Indianapolis · USIndiana University School of Medicine

Funding

Manipulation of STAT3 Signaling for Muscle Preservation in Cancer CachexiaR01CA122596 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ZIMMERS, TERESA A · 2010 to 2015
$1.6M
PQB3: Mechanisms & Targeting of Sonic Hedgehog Signaling in Muscle Wasting of Cancer CachexiaR01CA194593 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI ZIMMERS, TERESA A · 2015 to 2018
$1.4M
NCI NIH HHS R01 CA122596NCI NIH HHS R01 CA194593
6 · The paper itself

Abstract

purpose of reviewIn this article, we will discuss the current understanding of bone pain and muscle weakness in cancer patients. We will describe the underlying physiology and mechanisms of cancer-induced bone pain (CIBP) and cancer-induced muscle wasting (CIMW), as well as current methods of diagnosis and treatment. We will discuss future therapies and research directions to help patients with these problems. RECENT

findingsThere are several pharmacologic therapies that are currently in preclinical and clinical testing that appear to be promising adjuncts to current CIBP and CIMW therapies. Such therapies include resiniferitoxin, which is a targeted inhibitor of noceciptive nerve fibers, and selective androgen receptor modulators, which show promise in increasing lean mass. CIBP and CIMW are significant causes of morbidity in affected patients. Current management is mostly palliative; however, targeted therapies are poised to revolutionize how these problems are treated.

Indexed as

Bone and BonesBone DiseasesBone NeoplasmsCachexiaCancer PainHumansHypercalcemiaMuscle WeaknessNeoplasmsSarcopeniaBone metastasisCachexiaCancer-induced bone painMuscle weakness

Identifiers

PMID28497213
PMCPMC5778907
OpenAlexW2613928617

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.