ArticleAvicenna journal of medical biotechnology
Gestational Exposure to Silymarin Increases Susceptibility of BALB/c Mice Fetuses to Apoptosis.
Article in Avicenna journal of medical biotechnology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- JAK/STAT signaling in diabetic kidney disease.Frontiers in cell and developmental biology · 2023Review
- Investigating the effect of Swedish massage with chamomile oil on labor pain and anxiety of primiparous women: A clinical trial.Journal of education and health promotion · 2023Article
- The effect of auriculotherapy on improving sleep quality in postmenopausal women aged 45-60 years: A clinical trial study.Journal of education and health promotion · 2022Article
- The effect of holding a workshop (group and face-to-face training method) on nutrition adjustment on anthropometric indices in children with chronic liver disease.Journal of education and health promotion · 2022Article
- The effect of nutritional education program on micronutrient intake in children with chronic liver disease: A clinical trial.Journal of education and health promotion · 2021Article
- Evaluation of the effect of education on perceived stress of mother candidates for amniocentesis.Journal of education and health promotion · 2021Article
- Role of judgment in promoting nurses' decisions and ethical behavior.Journal of education and health promotion · 2021Article
- Investigating the relationship between the dimensions of mindfulness and maternal attachment to the fetus during pregnancy.Journal of education and health promotion · 2021Article
- Effect of education on knowledge of fertility counseling and attitudes toward fertility control.Journal of education and health promotion · 2021Article
- Adjuvant Therapy with Silibinin Improves the Efficacy of Paclitaxel and Cisplatin in MCF-7 Breast Cancer CellsAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Silibinin improved the function of T cells in peripheral blood mononuclear cells (PBMCs) co-cultured with U-87 MG cell line.Avicenna journal of phytomedicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSilymarin is a flavonolignan that has been the subject of research to evaluate the beneficial properties for decades. Silymarin has been known for its potent cytoprotective, hepatoprotective and antioxidant activities. The goal of the present study was to gain a deeper understanding of possible molecular mechanisms of apoptosis of the injuries induced by silymarin on BALB/c mice fetuses.
methodsThe present experimental study was carried out in virgin female BALB/c mice. The animals were divided randomly into 4 groups. Three test groups were injected intraperitoneally with silymarin at doses of 50, 100 and 200
resultsThe results of this study showed that silymarin administration during organogenesis at doses of 50, 100 and 200
conclusionAccording to the results, programmed cell death, especially via the intrinsic pathway, plays a pivotal role in the pathogenesis of silymarin-induced malformations in some tissue including heart, kidneys and brain. More studies are needed to determine other molecular mechanisms underlying silymarin- induced embryo toxicity.
Indexed as
Identifiers
28496945PMC5410131W2609944459What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.