ReviewJournal of clinical medicine research2017
C-Reactive Protein and Frailty in the Elderly: A Literature Review.
Review in Journal of clinical medicine research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Frailty in COPD: Clinical Impact, Diagnosis, Biomarkers, and Management Strategies.International journal of chronic obstructive pulmonary disease · 2025Pooled it
- Frailty affects prognosis in patients with colorectal cancer: A systematic review and meta-analysis.Frontiers in oncology · 2022Pooled it
- Iron deficiency and biomarkers of inflammation: a 3-year prospective analysis of the DO-HEALTH trial.Aging clinical and experimental research · 2022Trial
- Identifying Frail-Related Biomarkers among Community-Dwelling Older Adults in Japan: A Research Example from the Japanese Gerontological Evaluation Study.BioMed research international · 2018Trial
- Trial
- Article
- Lung function change and quantitative computed tomography measurements are associated with prospective frailty.ERJ open research · 2026Article
- State educational contexts in childhood and systemic inflammation in later life: Evidence from the health and retirement study.Brain, behavior, & immunity - health · 2026Article
- Frailty transitions and associated factors in older cancer survivors in the USA: using a multi-state modeling.Journal of cancer survivorship : research and practice · 2026Article
- Persistently raised inflammatory markers in a patient with resolved lower respiratory tract infection: a diagnostic challenge.Oxford medical case reports · 2026Article
- The Association Between Inflammatory Scores and Frailty Severity: An Exploratory Retrospective Analysis in Non-Small-Cell Lung Cancer Surgical Patients.Medical sciences (Basel, Switzerland) · 2026Article
- Inflammation meets insulin resistance: the role of the CRP-triglyceride-glucose index in association with frailty among middle-aged and older adults in China.European journal of medical research · 2026Article
- Physical frailty in relation to immunosenescence involving pDC function in the Japanese elderly: a cross-sectional survey study.Immunity & ageing : I & A · 2026Article
- [Association between daytime napping and depressive symptoms in older women: The chain mediating role of frailty and C-reactive protein].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Article
- Epigenetic Age Monitoring in Professional Soccer Players for Tracking Recovery and the Effects of Strenuous Exercise.Aging cell · 2025Observational
- Development and validation of an interpretable nomogram for predicting the risk of the prolonged postoperative length of stay for tuberculous spondylitis: a novel approach for risk stratification.BMC musculoskeletal disorders · 2025Article
- Aging enhances pro-atrogenic gene expression and skeletal muscle loss following respiratory syncytial virus infection.GeroScience · 2025Article
- Examining the relationship between biomarkers of immune aging and prevalent physical disability in the health and retirement study.Brain, behavior, and immunity · 2025Article
- Clinical impact of low bone mineral density in patients with colorectal cancer liver metastasis undergoing hepatectomy.PloS one · 2025Article
- C-reactive Protein-albumin-lymphocyte Index Is a Useful Indicator for Recurrence and Survival Following Curative Resection of Stage I-III Colorectal Cancer.Journal of the anus, rectum and colon · 2025Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic inflammation is a well-established background process in many age-related diseases. Many recent studies investigate the use of various inflammatory biomarkers such as C-reactive protein (CRP), interleukin-6, and interleukin-1 as predictors of physical and cognitive performance among elders. The phenotype of frailty has also been associated with underlying inflammatory mechanisms. The aim of this article was to review the literature referring to the correlation of CRP serum levels and frailty in older individuals. We tried to identify all relevant publications regarding the relation of CRP as an index of frailty in the elderly and its potential use. Although many studies in the recent medical literature positively associate serum CRP levels and frailty in older individuals, some do not, and some raise some interesting questions and set the basis for future studies. The association of CRP and frailty in elder patients should be considered when clinicians interpret inflammatory biomarkers in various clinical settings in such patients. Well-designed, prospective clinical trials are warranted to better assess the role and pathophysiology of frailty in the elderly and its mechanisms as also the exact role of CRP as an inflammatory marker and as a prognostic index in this syndrome.
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