Evidence map›Paper›PMID 28496287›Full record

ArticleChemical engineering research & design : transactions of the Institution of Chemical Engineers2016

A systems theoretic approach to analysis and control of mammalian circadian dynamics.

John H Abel, Francis J Doyle

Abstract read
In one paragraph

Article in Chemical engineering research & design : transactions of the Institution of Chemical Engineers, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Mathematical modeling of circadian rhythms.Wiley interdisciplinary reviews. Systems biology and medicine · 2019
    Review
  7. Pharmaceutical-based entrainment of circadian phase via nonlinear model predictive control.Automatica : the journal of IFAC, the International Federation of Automatic Control · 2019
    Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

John H AbelDepartment of Systems Biology, Harvard Medical School, Boston, MA 02115.
Francis J DoyleHarvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138.

Funding

TRAINING IN SLEEP, CIRCADIAN &RESPIRATORY NEUROBIOLOGYT32HL007901 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Charles A Czeisler · 1998 to 2026
$18.5M
MECHANISMS AND MODELING OF NETWORKED CIRCADIAN PACEMAKER SYNCHRONIZATIONR01GM096873 · NIGMS · WASHINGTON UNIVERSITY · PI DOYLE, FRANCIS J, HENSON, MICHAEL · 2011 to 2014
$1.1M
NHLBI NIH HHS T32 HL007901NIGMS NIH HHS R01 GM096873
6 · The paper itself

Abstract

The mammalian circadian clock is a complex multi-scale, multivariable biological control system. In the past two decades, methods from systems engineering have led to numerous insights into the architecture and functionality of this system. In this review, we examine the mammalian circadian system through a process systems lens. We present a mathematical framework for examining the cellular circadian oscillator, and show recent extensions for understanding population-scale dynamics. We provide an overview of the routes by which the circadian system can be systemically manipulated, and present

Indexed as

biomedical controlcircadian rhythmnonlinear dynamicsprocess controlSystems biology

Identifiers

PMID28496287
PMCPMC5421650

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.