ArticleScientific reports2017
The caterpillar fungus, Ophiocordyceps sinensis, genome provides insights into highland adaptation of fungal pathogenicity.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44 citing papers in PubMed, 95 citations in OpenAlex.
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- Article
- Whole genome sequencing and resequencing provide insight into the genetic structure of wild Ophiocordyceps sinensis.BMC genomics · 2025Article
- Genomic Insights Into Convergent Evolution: Adaptation to Rocky Habitats in Rock-Inhabiting Fungi.Molecular biology and evolution · 2025Article
- Haplotype-Phased Chromosome-Level Genome Assembly ofJournal of fungi (Basel, Switzerland) · 2025Article
- Three-Dimensional Structural Heteromorphs of Mating-Type Proteins inJournal of fungi (Basel, Switzerland) · 2025Article
- The Importance of Edible Medicinal Mushrooms and Their Potential Use as Therapeutic Agents Against Insulin Resistance.International journal of molecular sciences · 2025Review
- Whole-Genome Sequence Analysis ofJournal of fungi (Basel, Switzerland) · 2024Article
- Translation of Mutant Repetitive Genomic Sequences inInternational journal of molecular sciences · 2024Article
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- Mutations and Differential Transcription of Mating-Type and Pheromone Receptor Genes inBiology · 2024Article
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- Selection and validation of reference genes for RT-qPCR in ophiocordyceps sinensis under different experimental conditions.PloS one · 2024Article
- Unveiling mycoviral diversity inFrontiers in microbiology · 2024Article
- Transcriptome and metabonomics combined analysis revealed the energy supply mechanism involved in fruiting body initiation in Chinese cordyceps.Scientific reports · 2023Article
- The phylogeny and divergence time of Ophiocordyceps sinensis and its host insects based on elongation factor 1 alpha.Archives of microbiology · 2023Article
- Unraveling the Secrets of a Double-Life Fungus by Genomics:Journal of fungi (Basel, Switzerland) · 2023Article
- Isolation of strains and their genome sequencing to analyze the mating system of Ophiocordyceps robertsii.PloS one · 2023Article
- Systematic analyses with genomic and metabolomic insights reveal a new species,Frontiers in microbiology · 2023Article
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17 authors at 7 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
To understand the potential genetic basis of highland adaptation of fungal pathogenicity, we present here the ~116 Mb de novo assembled high-quality genome of Ophiocordyceps sinensis endemic to the Qinghai-Tibetan Plateau. Compared with other plain-dwelling fungi, we find about 3.4-fold inflation of the O. sinensis genome due to a rapid amplification of long terminal repeat retrotransposons that occurred ~38 million years ago in concert with the uplift of the plateau. We also observe massive removal of thousands of genes related to the transport process and energy metabolism. O. sinensis displays considerable lineage-specific expansion of gene families functionally enriched in the adaptability of low-temperature of cold tolerance, fungal pathogenicity and specialized host infection. We detect signals of positive selection for genes involved in peroxidase and hypoxia to enable its highland adaptation. Resequencing and analyzing 31 whole genomes of O. sinensis, representing nearly all of its geographic range, exhibits latitude-based population divergence and nature selection for population inhabitation towards higher altitudes on the Qinghai-Tibetan Plateau.
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