Evidence map›Paper›PMID 28496169›Full record

ArticleScientific reports2017

Exploring the link between cadmium and psoriasis in a nationally representative sample.

Fang-Yih Liaw, Wei-Liang Chen, Tung-Wei Kao, Yaw-Wen Chang, Ching-Fu Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.

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  13. Unveiling Psoriasis: Delving into Pathogenesis, Treatment Breakthroughs, and Patent Trends.Recent advances in inflammation & allergy drug discovery · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Fang-Yih LiawFamily Medicine and Geriatric Medicine, Department of Family and Community health, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Wei-Liang ChenFamily Medicine and Geriatric Medicine, Department of Family and Community health, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Tung-Wei KaoFamily Medicine and Geriatric Medicine, Department of Family and Community health, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Yaw-Wen ChangFamily Medicine and Geriatric Medicine, Department of Family and Community health, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.ORCID 0000-0002-8436-0518
Ching-Fu HuangDepartment of Dermatology, Taoyuan Armed Forces General Hospital, Taoyuan and National Defense Medical Center, Taipei, Taiwan. lamoneparrot@hotmail.com.
Tri-Service General Hospital · TWTaoyuan Armed Forces General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psoriasis, a skin inflammatory disease, originates from dysregulated interactions of the immune system. Cadmium, an environment pollutant, increases the levels of inflammation markers and influences the immune system. To clarify the relationship between cadmium and psoriasis, 5,927 participants, ≥20 years, in the National Health and Nutrition Examination Survey (NHANES) 2003-2006 were studied. Psoriasis severity was assessed using self-reported dermatology questionnaires. Cadmium was measured using blood chemistry. Three adjusted models were applied for the interaction between serum cadmium and severity of psoriasis. Psoriasis patients had significantly higher blood cadmium (0.67 vs. 0.52 μg/L, p = 0.006). There was a strong linear increase in predicted blood cadmium values with an increase in severity of psoriasis (p for trend = 0.002). The β coefficient of the predicted serum cadmium in the "few patches to extensive psoriasis" group was 0.234 (p = 0.002) after adjusting covariates. Participants with severe psoriasis have higher blood cadmium. Environmental exposure to cadmium can predispose to the worsening of psoriasis. Although there are still limitations in this study, such as not included treatment data, these results have substantial public health implications for the general population, as they demonstrate the importance of cadmium exposure prevention, particularly among psoriasis patients.

Indexed as

AdultCadmiumFemaleHumansMalePsoriasisRegression AnalysisSeverity of Illness IndexCadmium

Identifiers

PMID28496169
PMCPMC5431928
OpenAlexW2611047700

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.