ArticleScientific reports2017
Systematic evaluation for effects of urine pH on calcium oxalate crystallization, crystal-cell adhesion and internalization into renal tubular cells.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 115 citations in OpenAlex.
- Article
- Urinary proteins from stone formers promote calcium oxalate crystallization, growth and aggregation via oxidative modifications.Journal of advanced research · 2026Article
- Article
- Systematic evaluation and comparison of theCurrent research in food science · 2026Article
- Neurochemical profiling in urine: Multiplexed detection of dopamine and serotonin using ML-integrated laser-induced graphene biosensors.Biosensors & bioelectronics · 2025Article
- Modulators of urinary pH in the context of urinary stone disease: a literature review.Translational andrology and urology · 2025Review
- Therapeutic potential of seaweeds and their biofabricated nanoparticles in treating urolithiasis: A review.Heliyon · 2025Review
- ACOT4 and ACOT6 Activate Akt-mTOR Pathway and Inhibit Calcium Oxalate-Induced Renal Tubular Cell Injury.Kidney & blood pressure research · 2025Article
- Selenium participates in the formation of kidney stones by alleviating endoplasmic reticulum stress and apoptosis of renal tubular epithelial cells.Redox report : communications in free radical research · 2024Article
- Higher dietary insulin index is directly associated with the odd of kidney stones.Scientific reports · 2024Article
- Evaluating the lipid accumulation product index as a predictor for kidney stone prevalence: insights from NHANES 2007-2018.International urology and nephrology · 2024Observational
- Sex-specific Stone-forming Phenotype in Mice During Hypercalciuria/Urine Alkalinization.Laboratory investigation; a journal of technical methods and pathology · 2024Article
- Tight junction and kidney stone disease.Tissue barriers · 2024Review
- Resveratrol inhibits calcium oxalate crystal growth, reduces adhesion to renal cells and induces crystal internalization into the cells, but promotes crystal aggregation.Current research in food science · 2024Article
- Increased risk of chronic kidney disease in uric acid stone formers with high neutrophil-to-lymphocyte ratio.Scientific reports · 2023Article
- Retrospective analysis of urinary tract stone composition in a Chinese ethnic minority colony based on Fourier transform infrared spectroscopy.Scientific reports · 2023Article
- Oxalate Homeostasis in Non-Stone-Forming Chronic Kidney Disease: A Review of Key Findings and Perspectives.Biomedicines · 2023Review
- Clinical characteristics of surgically managed patients with asymptomatic renal stones: Comparison of patients with symptomatic renal stones.Investigative and clinical urology · 2023Article
- Sex disparities and the risk of urolithiasis: a large cross-sectional study.Annals of medicine · 2022Article
- Roles of heat-shock protein 90 and its four domains (N, LR, M and C) in calcium oxalate stone-forming processes.Cellular and molecular life sciences : CMLS · 2022Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Urine pH has been thought to be an important factor that can modulate kidney stone formation. Nevertheless, there was no systematic evaluation of such pH effect. Our present study thus addressed effects of differential urine pH (4.0-8.0) on calcium oxalate (CaOx) crystallization, crystal-cell adhesion, crystal internalization into renal tubular cells, and binding of apical membrane proteins to the crystals. Microscopic examination revealed that CaOx monohydrate (COM), the pathogenic form, was crystallized with greatest size, number and total mass at pH 4.0 and least crystallized at pH 8.0, whereas COD was crystallized with the vice versa order. Fourier-transform infrared (FT-IR) spectroscopy confirmed such morphological study. Crystal-cell adhesion assay showed the greatest degree of crystal-cell adhesion at the most acidic pH and least at the most basic pH. Crystal internalization assay using fluorescein isothiocyanate (FITC)-labelled crystals and flow cytometry demonstrated that crystal internalization into renal tubular cells was maximal at the neutral pH (7.0). Finally, there were no significant differences in binding capacity of the crystals to apical membrane proteins at different pH. We concluded that the acidic urine pH may promote CaOx kidney stone formation, whereas the basic urine pH (i.e. by alkalinization) may help to prevent CaOx kidney stone disease.
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