Evidence map›Paper›PMID 28496093›Full record

SynthesisMedical science monitor basic research2017

Prediction of New-Onset and Recurrent Atrial Fibrillation by Complete Blood Count Tests: A Comprehensive Systematic Review with Meta-Analysis.

Alexander Weymann, Sadeq Ali-Hasan-Al-Saegh, Anton Sabashnikov, Aron-Frederik Popov, Seyed Jalil Mirhosseini, Tong Liu, Mohammadreza Lotfaliani, Michel Pompeu Barros de Oliveira Sá, William L L Baker, Senol Yavuz and 16 more

Open access · greenAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Medical science monitor basic research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 18 institutions in 11 countries.

Alexander WeymannDepartment of Cardiac Surgery, University Hospital Oldenburg, European Medical School Oldenburg-Groningen, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.
Sadeq Ali-Hasan-Al-SaeghAfshar Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Anton SabashnikovDepartment of Cardiothoracic Transplantation and Mechanical Circulatory Support, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom.
Aron-Frederik PopovDepartment of Cardiothoracic Transplantation and Mechanical Circulatory Support, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom.
Seyed Jalil MirhosseiniCardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Isfahan, Iran.
Tong LiuTianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, China (mainland).
Mohammadreza LotfalianiCardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Isfahan, Iran.
Michel Pompeu Barros de Oliveira SáDivision of Cardiovascular Surgery, Pronto Socorro Cardiológico de Pernambuco - PROCAPE, Recife, Brazil.
William L L BakerDepartment of Pharmacy, University of Connecticut/Hartford Hospital Evidence-Based Practice Center, Hartford, CT, USA.
Senol YavuzDepartment of Cardiovascular Surgery, Bursa Yuksek Ihtisas Training and Research Hospital, Yıldırım/Bursa, Turkey.
Mohamed ZeriouhDepartment of Cardiothoracic Transplantation and Mechanical Circulatory Support, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom.
Jae-Sik JangDepartment of Cardiology, Busan Paik Hospital, Inje University College of Medicine, Jin-gu, Korea, Democratic People's Republic of.
Hamidreza DehghanDepartment of Health Technology Assessment, Shahid Sadoughi University of Medical Sciences and Health Services, Isfahan, Iran.
Lei MengTianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, China (mainland).
Luca TestaDepartment of Cardiology, IRCCS Pol. S. Donato, San Donato Milanese, Italy.
Fabrizio D'AscenzoDivision of Cardiology, Department of Medical Sciences, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy.
Umberto BenedettoBristol Heart Institute, University of Bristol, School of Clinical Sciences, Bristol, United Kingdom.
Gary TseDepartment of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong.
Luis Nombela-FrancoInstituto Cardiovascular, Hospital Universitario Clínico San Carlos, Madrid, Spain.
Pascal M DohmenDepartment of Cardiac Surgery, University Hospital Oldenburg, European Medical School Oldenburg-Groningen, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.
Abhishek J DeshmukhMayo Clinic Heart Rhythm Section, Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.
Cecilia LindeDepartment of Cardiology, Karolinska University Hospital, Karolinska Institut, Solna, Sweden.
Giuseppe Biondi-ZoccaiDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
Gregg W StoneNew York Presbyterian Hospital, Columbia University Medical Center, New York, NY, USA.
Hugh CalkinsDepartment of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Integrated Meta-Analysis Of Cardiac Surgery And Cardiology-Group Imcsc-Group0, 0, 0.
Shahid Sadoughi University of Medical Sciences and Health Services · IRRoyal Brompton & Harefield NHS Foundation Trust · GBCarl von Ossietzky Universität Oldenburg · DEBursa Yuksek Ihtisas Egitim Ve Arastirma Hastanesi · TRChinese University of Hong Kong · HKHospital Clínico San Carlos · ESInje University Busan Paik Hospital · KRIRCCS Policlinico San Donato · ITJohns Hopkins University · USKarolinska University Hospital · SENewYork–Presbyterian Hospital · USNIHR Bristol Cardiovascular Biomedical Research Unit · GBSapienza University of Rome · ITSecond Hospital of Tianjin Medical University · CNTianjin Medical University · CNUniversity of Connecticut · USUniversity of Turin · ITWinnMed · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND Atrial fibrillation (AF) is one of the most critical and frequent arrhythmias precipitating morbidities and mortalities. The complete blood count (CBC) test is an important blood test in clinical practice and is routinely used in the workup of cardiovascular diseases. This systematic review with meta-analysis aimed to determine the strength of evidence for evaluating the association of hematological parameters in the CBC test with new-onset and recurrent AF. MATERIAL AND METHODS We conducted a meta-analysis of observational studies evaluating hematologic parameters in patients with new-onset AF and recurrent AF. A comprehensive subgroup analysis was performed to explore potential sources of heterogeneity. RESULTS The literature search of all major databases retrieved 2150 studies. After screening, 70 studies were analyzed in the meta-analysis on new-onset AF and 23 studies on recurrent AF. Pooled analysis on new-onset AF showed platelet count (PC) (weighted mean difference (WMD)=WMD of -26.39×10^9/L and p<0.001), mean platelet volume (MPV) (WMD=0.42 FL and p<0.001), white blood cell (WBC) (WMD=-0.005×10^9/L and p=0.83), neutrophil to lymphocyte ratio (NLR) (WMD=0.89 and p<0.001), and red blood cell distribution width (RDW) (WMD=0.61% and p<0.001) as associated factors. Pooled analysis on recurrent AF revealed PC (WMD=-2.71×109/L and p=0.59), WBC (WMD=0.20×10^9/L (95% CI: 0.08 to 0.32; p=0.002), NLR (WMD=0.37 and p<0.001), and RDW (WMD=0.28% and p<0.001). CONCLUSIONS Hematological parameters have significant ability to predict occurrence and recurrence of AF. Therefore, emphasizing the potential predictive role of hematological parameters for new-onset and recurrent AF, we recommend adding the CBC test to the diagnostic modalities of AF in clinical practice.

Indexed as

AgedAged, 80 and overAtrial FibrillationBlood Cell CountFemaleForecastingHumansMaleMean Platelet VolumeMiddle AgedPlatelet Count

Identifiers

PMID28496093
PMCPMC5439535
OpenAlexW2613045934

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.