ReviewThe Journal of reproduction and development2017
Effects of heat stress on bovine preimplantation embryos produced in vitro.
Review in The Journal of reproduction and development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 75 citations in OpenAlex.
- The Effect of Heat Treatment on the Gene Expression and Cryosurvival of In Vitro-Produced Bovine Embryos.Animals : an open access journal from MDPI · 2026Article
- Ovarian Function, Hormonal, Metabolic, Oxidative Stress, and Gene Expression Biomarker Responses of Holstein Heifers Under Heat Stress Conditions to a Reduced Dose of Nanofabricated GnRH Analog Within the Ovsynch Protocol.Animals : an open access journal from MDPI · 2026Article
- In vivo use of melatonin improves oocyte developmental competence and blastocyst development rate in indigenous donor cow during summer.Tropical animal health and production · 2026Article
- Reactive Oxygen Species in Embryo Development: Sources, Impacts, and Implications for In Vitro Culture Systems.Life (Basel, Switzerland) · 2026Review
- Influence of heat stress and nighttime recovery on ovarian follicle population, oocyte yield, and in vitro embryo production in Holstein heifers.Archives animal breeding · 2026Article
- Heat stress modulates extracellular vesicles miRNA cargo in bovine uterine fluid and uterine function.Frontiers in veterinary science · 2026Article
- Molecular and developmental consequences of heat stress on the bovine oocyte and embryo competence.Animal reproduction · 2026Article
- Timing of human chorionic gonadotropin administration affects conception rates after embryo transfer in crossbred beef heifers.The Journal of veterinary medical science · 2025Article
- Effect of heat stress on some serum and reproductive parameters of Holstein dairy cows in Egypt: potential biomarkers.BMC veterinary research · 2025Article
- The Effect of Heat Stress During the Insemination Period on the Conception Outcomes of Dairy Cows.Animals : an open access journal from MDPI · 2025Article
- Effect of the addition of IGF-1 during in vitro culture on the embryonic development speed from different crossbreed bovine embryos.Tropical animal health and production · 2024Article
- Transcriptome analysis of the effects of high temperature on zygotic genome activation in porcine embryos.Scientific reports · 2024Article
- Utilization of Assisted Reproductive Technologies in Breeding Auliekol Cattle: A Comparative Study.Life (Basel, Switzerland) · 2024Article
- Impact of Heat Stress on Oocyte Developmental Competence and Pre-Implantation Embryo Viability in Cattle.Animals : an open access journal from MDPI · 2024Review
- In Vitro Embryos of Romosinuano and Tropical Milking Cattle during Three Seasons in Veracruz, Mexico.Animals : an open access journal from MDPI · 2024Article
- Heat-Stress Impacts on Developing Bovine Oocytes: Unraveling Epigenetic Changes, Oxidative Stress, and Developmental Resilience.International journal of molecular sciences · 2024Article
- Clinical Benefits of Decreased Photo-Oxidative Stress on Human Embryo Development.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2024Article
- Seasonal distribution of repeat breeder cows and evaluation of modified protocols for post AI treatment during summer.Tropical animal health and production · 2023Article
- Article
- Improved pregnancy rate and sex ratio in fresh/frozenJournal of animal science and technology · 2023Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Summer heat stress decreases the pregnancy rate in cattle and has been thought to be associated with the early embryonic death caused by the elevation of maternal body temperature. In vitro cultures have been widely used for the evaluation of effects of heat stress on oocytes, fertilization, preimplantation, and embryonic development. Susceptibility to heat stress is present in developmental stages from oocytes to cleavage-stage (before embryonic gene activation, EGA) embryos, leading to a consequent decrease in developmental competence. On the other hand, advanced-stage embryos such as morula or blastocysts have acquired thermotolerance. The mechanism for the developmental stage-dependent change in thermotolerance is considered to be the accumulation of antioxidants in embryos in response to heat-inducible production of reactive oxygen species. The supplementation of antioxidants to the culture media has been known to neutralize the detrimental effects of heat stress. Besides, EGA could be involved in acquisition of thermotolerance in later stages of embryos. Morulae or blastocysts can repair heat-induced unfolded proteins or prevent DNA damage occurring in processes such as apoptosis. Therefore, embryo transfer (ET) that can bypass the heat-sensitive stage could be a good solution to improve the pregnancy rate under heat stress. However, frozen-thawed ET could not improve the pregnancy rate as expected. Frozen-thawed blastocysts were more sensitive to heat stress and showed less proliferation upon heat exposure, compared to fresh blastocysts. Therefore, further research is required to improve the reduction in pregnancy rates due to summer heat stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.