Evidence map›Paper›PMID 28495975›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

Short-Term Depression of Sprouted Mossy Fiber Synapses from Adult-Born Granule Cells.

William D Hendricks, Yang Chen, AeSoon L Bensen, Gary L Westbrook, Eric Schnell

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Robust PHP in Adult Hippocampus: Essential Assay Optimizations.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Adult-Born Granule Cells Contribute to Dentate Gyrus Circuit Reorganization after Traumatic Brain Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  5. Review
  6. Article
  7. Adult Born Dentate Granule Cell Mediated Upregulation of Feedback Inhibition in a Mouse Model of Traumatic Brain Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  8. Adaptive Mossy Cell Circuit Plasticity after Status Epilepticus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  9. Review
  10. Article
  11. Review
  12. Altered Synaptic Drive onto Birthdated Dentate Granule Cells in Experimental Temporal Lobe Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Article
  13. Article
  14. Early detonation by sprouted mossy fibers enables aberrant dentate network activity.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

William D HendricksNeuroscience Graduate Program.ORCID 0000-0003-2841-577X
Yang ChenVollum Institute, and.
AeSoon L BensenVollum Institute, and.
Gary L WestbrookVollum Institute, and.ORCID 0000-0002-8108-5223
Eric SchnellDepartment of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, Oregon 97239, and schneler@ohsu.edu.ORCID 0000-0002-5623-5015
Vollum Institute · USOregon Health & Science University · US

Funding

Ultrastructure and Single Particle Microscopy CoreP30NS061800 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI AICHER, SUE A · 2009 to 2020
$6.6M
Transcriptional analysis of adult newborn hippocampal neuronsR01NS080979 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI GOODMAN, RICHARD H. · 2013 to 2016
$1.3M
Functional Role of Neurogenesis in Hippocampal Mossy Fiber SproutingF31NS098597 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI HENDRICKS, WILLIAM DAVID · 2016 to 2018
$108k
Functional contribution of adult-born neurons to epileptogenesisI01BX002949 · VA · PORTLAND VA MEDICAL CENTER · PI SCHNELL, ERIC · 2016 to 2019
–
BLRD VA I01 BX002949NINDS NIH HHS F31 NS098597NINDS NIH HHS P30 NS061800NINDS NIH HHS R01 NS080979
6 · The paper itself

Abstract

Epileptic seizures potently modulate hippocampal adult neurogenesis, and adult-born dentate granule cells contribute to the pathologic retrograde sprouting of mossy fiber axons, both hallmarks of temporal lobe epilepsy. The characteristics of these sprouted synapses, however, have been largely unexplored, and the specific contribution of adult-born granule cells to functional mossy fiber sprouting is unknown, primarily due to technical barriers in isolating sprouted mossy fiber synapses for analysis. Here, we used

Indexed as

Neural InhibitionNeuronsSynapsesSynaptic TransmissionAnimalsMaleMiceMice, TransgenicMossy Fibers, HippocampalNeurogenesisSeizuresadult neurogenesisdentateepilepsymossy fiberseizuresprouting

Identifiers

PMID28495975
PMCPMC5469308
OpenAlexW2614066616

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.