ArticleGenetics2017
Inferring the Joint Demographic History of Multiple Populations: Beyond the Diffusion Approximation.
Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 144 papers.
What it found
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Who cites it
144 citing papers in PubMed.
- Article
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- Faster inference of complex demographic models from large allele frequency spectra.Bioinformatics (Oxford, England) · 2026Article
- Neural posterior estimation for population genetics.Genetics · 2026Article
- Expansion From Lowland Pleistocene Refugia Followed by Cryptic Introgression in an African Elevational Generalist Bird.Molecular ecology · 2026Article
- Mixed Support for Pleistocene Sea-Level Fluctuations in Promoting the Diversification of Anole Lizards in the Northern Lesser Antilles.Molecular ecology · 2026Article
- Quaternary Climatic Changes and Biogeographic Barriers Drove Codiversification in the Obligate Mutualism BetweenEcology and evolution · 2026Article
- CoalMiner: a coalescent model generator forbioRxiv : the preprint server for biology · 2026Article
- Genomic and palaeoclimatic data reveal Pleistocene adaptation and diversification of non-model bluegrasses (Poa sect. Stenopoa) in cold, arid environments.Communications biology · 2026Article
- Causal inference clarifies the roles of background selection and mutation rate variation in shaping human genetic diversity.bioRxiv : the preprint server for biology · 2026Article
- Allele Frequency Spectra as a General Tool for Modeling Genetic Diversity.Acta biotheoretica · 2026Article
- Multiscale genetic connectivity, kinship, and demographic history of the Antarctic soft coral Alcyonium antarcticum in the Western Antarctic Peninsula.Scientific reports · 2026Article
- Article
- General, orders-of-magnitude faster whole-genome analysis with genotype representation graphs.bioRxiv : the preprint server for biology · 2026Article
- Seizure samples reveal complex evolutionary dynamics among Southeast Asian pangolins.Heredity · 2026Article
- Neural posterior estimation for population genetics.bioRxiv : the preprint server for biology · 2026Article
- Estimating the Reduction in Genetic Diversity from Background Selection under Non-equilibrium Demography and Partial Selfing.Molecular biology and evolution · 2026Article
- GENERAL MOMENT CLOSURE FOR THE NEUTRAL TWO-LOCUS WRIGHT-FISHER DYNAMICS.bioRxiv : the preprint server for biology · 2026Article
- PhaseGen: exact solutions for time-inhomogeneous multivariate coalescent distributions under diverse demographies.Genetics · 2026Article
84 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
Abstract
Understanding variation in allele frequencies across populations is a central goal of population genetics. Classical models for the distribution of allele frequencies, using forward simulation, coalescent theory, or the diffusion approximation, have been applied extensively for demographic inference, medical study design, and evolutionary studies. Here we propose a tractable model of ordinary differential equations for the evolution of allele frequencies that is closely related to the diffusion approximation but avoids many of its limitations and approximations. We show that the approach is typically faster, more numerically stable, and more easily generalizable than the state-of-the-art software implementation of the diffusion approximation. We present a number of applications to human sequence data, including demographic inference with a five-population joint frequency spectrum and a discussion of the robustness of the out-of-Africa model inference to the choice of modern population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.