ArticleGenetics2017
Resolving the Complex Genetic Basis of Phenotypic Variation and Variability of Cellular Growth.
Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- High-resolution genotype-free mapping of genetic variation with CRI-SPA-Map.Genome research · 2026Article
- Epistasis and cryptic QTL identified using modified bulk segregant analysis of copper resistance in budding yeast.Genetics · 2025Article
- Epistasis and cryptic QTL identified using modified bulk segregant analysis of copper resistance in budding yeast.bioRxiv : the preprint server for biology · 2024Article
- Fitness cost associated with cell phenotypic switching drives population diversification dynamics and controllability.Nature communications · 2023Article
- High-Throughput Live Imaging of Microcolonies to Measure Heterogeneity in Growth and Gene Expression.Journal of visualized experiments : JoVE · 2021Article
- Identification of novel genes involved in neutral lipid storage by quantitative trait loci analysis of Saccharomyces cerevisiae.BMC genomics · 2021Article
- Insights on the Control of Yeast Single-Cell Growth Variability by Members of the Trehalose Phosphate Synthase (TPS) Complex.Frontiers in cell and developmental biology · 2021Article
- Article
- Extent and context dependence of pleiotropy revealed by high-throughput single-cell phenotyping.PLoS biology · 2020Article
- Evolution of Microbial Growth Traits Under Serial Dilution.Genetics · 2020Article
- Genetic interaction profiles of regulatory kinases differ between environmental conditions and cellular states.Molecular systems biology · 2020Article
- Wild Yeast for the Future: Exploring the Use of Wild Strains for Wine and Beer Fermentation.Frontiers in genetics · 2020Review
- An evolving view of copy number variants.Current genetics · 2019Review
- Article
- Isolating and quantifying the role of developmental noise in generating phenotypic variation.PLoS computational biology · 2019Article
- Control of nongenetic heterogeneity in growth rate and stress tolerance of Saccharomyces cerevisiae by cyclic AMP-regulated transcription factors.PLoS genetics · 2018Article
- Growth tradeoffs produce complex microbial communities on a single limiting resource.Nature communications · 2018Article
- Linkage mapping of yeast cross protection connects gene expression variation to a higher-order organismal trait.PLoS genetics · 2018Article
- Molecular Ecological Basis of Grasshopper (Frontiers in physiology · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
In all organisms, the majority of traits vary continuously between individuals. Explaining the genetic basis of quantitative trait variation requires comprehensively accounting for genetic and nongenetic factors as well as their interactions. The growth of microbial cells can be characterized by a lag duration, an exponential growth phase, and a stationary phase. Parameters that characterize these growth phases can vary among genotypes (phenotypic variation), environmental conditions (phenotypic plasticity), and among isogenic cells in a given environment (phenotypic variability). We used a high-throughput microscopy assay to map genetic loci determining variation in lag duration and exponential growth rate in growth rate-limiting and nonlimiting glucose concentrations, using segregants from a cross of two natural isolates of the budding yeast,
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