ArticleAJNR. American journal of neuroradiology2017
Pontomesencephalic Atrophy and Postural Instability in Wilson Disease.
Article in AJNR. American journal of neuroradiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Phenotype-specific white matter microstructural alterations and their clinical correlates in Wilson disease.Scientific reports · 2026Article
- Identification of optimal value of magnetic resonance planimetry and the parkinsonism index for the diagnosis of Parkinson's disease and progressive supranuclear palsy.Journal of Taibah University Medical Sciences · 2023Article
- A Study of Dopaminergic Pathway in Neurologic Wilson Disease with Movement Disorder.Molecular neurobiology · 2023Article
- A study of linear measurement and clinical correlation of brain atrophy in Wilson's disease.Frontiers in human neuroscience · 2023Article
- MR Imaging of the Brain in Neurologic Wilson Disease.AJNR. American journal of neuroradiology · 2019Article
- Wilson's Disease Update: An Indian Perspective.Annals of Indian Academy of NeurologyArticle
- Wilson's Disease Update: An Indian Perspective.Annals of Indian Academy of NeurologyArticle
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe MR Parkinsonism index helps in differentiating progressive supranuclear palsy from Parkinson disease and multisystem atrophy. Pontomesencephalic involvement is common in neurologic Wilson disease, but there is no prior study evaluating the MR Parkinsonism index and its indices in Wilson disease. We report the MR Parkinsonism index and its indices in Wilson disease and correlate these changes with clinical severity and postural reflex. MATERIALS AND
methodsThirteen individuals with neurologic Wilson disease were included, and their clinical details, including neurologic severity, postural reflex abnormality, and location of signal changes on MR imaging, were noted. The 3D BRAVO T1 sequence was used for measurement of the MR Parkinsonism index and its indices. The MR Parkinsonism index and its indices were also obtained in 6 age- and sex-matched controls. The morphometric parameters in Wilson disease were compared with those in with healthy controls and among the patients with and without abnormal postural reflex.
resultsThe midbrain area was reduced in patients with Wilson disease compared with controls (112.08 ± 27.94 versus 171.95 ± 23.66 mm
conclusionsAn increase in the MR Parkinsonism index in Wilson disease is mainly due to midbrain atrophy and it correlates with neurologic severity and abnormal postural reflex.
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