Evidence map›Paper›PMID 28495929›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2017

Tissue Factor Prothrombotic Activity Is Regulated by Integrin-arf6 Trafficking.

Andrea S Rothmeier, Patrizia Marchese, Florian Langer, Yuichi Kamikubo, Florence Schaffner, Joseph Cantor, Mark H Ginsberg, Zaverio M Ruggeri, Wolfram Ruf

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. The Effect of Extracellular Vesicles on Thrombosis.Journal of cardiovascular translational research · 2023
    Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Roles of factor Xa beyond coagulation.Journal of thrombosis and thrombolysis · 2021
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Andrea S RothmeierFrom the Department of Immunology and Microbiology (A.S.R., F.S., W.R.) and Molecular Medicine (P.M., Y.K., Z.M.R.), The Scripps Research Institute, La Jolla, CA; II. Medical Clinic and Polyclinic, University Medical Center Eppendorf, Hamburg, Germany (F.L.); Department of Medicine, University of California San Diego, La Jolla (J.C., M.H.G.); Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, Mainz, Germany (W.R.).
Patrizia MarcheseFrom the Department of Immunology and Microbiology (A.S.R., F.S., W.R.) and Molecular Medicine (P.M., Y.K., Z.M.R.), The Scripps Research Institute, La Jolla, CA; II. Medical Clinic and Polyclinic, University Medical Center Eppendorf, Hamburg, Germany (F.L.); Department of Medicine, University of California San Diego, La Jolla (J.C., M.H.G.); Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, Mainz, Germany (W.R.).
Florian LangerFrom the Department of Immunology and Microbiology (A.S.R., F.S., W.R.) and Molecular Medicine (P.M., Y.K., Z.M.R.), The Scripps Research Institute, La Jolla, CA; II. Medical Clinic and Polyclinic, University Medical Center Eppendorf, Hamburg, Germany (F.L.); Department of Medicine, University of California San Diego, La Jolla (J.C., M.H.G.); Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, Mainz, Germany (W.R.).
Yuichi KamikuboFrom the Department of Immunology and Microbiology (A.S.R., F.S., W.R.) and Molecular Medicine (P.M., Y.K., Z.M.R.), The Scripps Research Institute, La Jolla, CA; II. Medical Clinic and Polyclinic, University Medical Center Eppendorf, Hamburg, Germany (F.L.); Department of Medicine, University of California San Diego, La Jolla (J.C., M.H.G.); Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, Mainz, Germany (W.R.).
Florence SchaffnerFrom the Department of Immunology and Microbiology (A.S.R., F.S., W.R.) and Molecular Medicine (P.M., Y.K., Z.M.R.), The Scripps Research Institute, La Jolla, CA; II. Medical Clinic and Polyclinic, University Medical Center Eppendorf, Hamburg, Germany (F.L.); Department of Medicine, University of California San Diego, La Jolla (J.C., M.H.G.); Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, Mainz, Germany (W.R.).
Joseph CantorFrom the Department of Immunology and Microbiology (A.S.R., F.S., W.R.) and Molecular Medicine (P.M., Y.K., Z.M.R.), The Scripps Research Institute, La Jolla, CA; II. Medical Clinic and Polyclinic, University Medical Center Eppendorf, Hamburg, Germany (F.L.); Department of Medicine, University of California San Diego, La Jolla (J.C., M.H.G.); Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, Mainz, Germany (W.R.).
Mark H GinsbergFrom the Department of Immunology and Microbiology (A.S.R., F.S., W.R.) and Molecular Medicine (P.M., Y.K., Z.M.R.), The Scripps Research Institute, La Jolla, CA; II. Medical Clinic and Polyclinic, University Medical Center Eppendorf, Hamburg, Germany (F.L.); Department of Medicine, University of California San Diego, La Jolla (J.C., M.H.G.); Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, Mainz, Germany (W.R.).
Zaverio M RuggeriFrom the Department of Immunology and Microbiology (A.S.R., F.S., W.R.) and Molecular Medicine (P.M., Y.K., Z.M.R.), The Scripps Research Institute, La Jolla, CA; II. Medical Clinic and Polyclinic, University Medical Center Eppendorf, Hamburg, Germany (F.L.); Department of Medicine, University of California San Diego, La Jolla (J.C., M.H.G.); Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, Mainz, Germany (W.R.).
Wolfram RufFrom the Department of Immunology and Microbiology (A.S.R., F.S., W.R.) and Molecular Medicine (P.M., Y.K., Z.M.R.), The Scripps Research Institute, La Jolla, CA; II. Medical Clinic and Polyclinic, University Medical Center Eppendorf, Hamburg, Germany (F.L.); Department of Medicine, University of California San Diego, La Jolla (J.C., M.H.G.); Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, Mainz, Germany (W.R.). ruf@scripps.edu.
Universität Hamburg · DEUniversity of California, San Diego · USUniversity Medical Center Hamburg-Eppendorf · DE

Funding

THROMBUS FORMATION IN BABOONSP01HL031950 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI GRIFFIN, JOHN H · 1985 to 2015
$29.4M
The Interaction of TPO and Integrins in Hematopoiesis CellsP01HL078784 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GINSBERG, MARK HOWARD · 2005 to 2019
$28.3M
Analysis and Characterization of Trauma-Induced CoagulopathyUM1HL120877 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI MORRISSEY, JAMES H., WISNIEWSKI, STEPHEN R · 2013 to 2019
$26.6M
SIGNALING OF TISSUE FACTOR IN CELL ADHESIONR01HL060742 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI RUF, WOLFRAM · 1998 to 2017
$6.4M
Platelet and coagulation activation in response to vascular injuryR01HL117722 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI RUGGERI, ZAVERIO M · 2015 to 2018
$2.3M
NHLBI NIH HHS P01 HL031950NHLBI NIH HHS P01 HL078784NHLBI NIH HHS R01 HL060742NHLBI NIH HHS R01 HL117722NHLBI NIH HHS UM1 HL120877
6 · The paper itself

Abstract

objectiveCoagulation initiation by tissue factor (TF) is regulated by cellular inhibitors, cell surface availability of procoagulant phosphatidylserine, and thiol-disulfide exchange. How these mechanisms contribute to keeping TF in a noncoagulant state and to generating prothrombotic TF remain incompletely understood. APPROACH AND

resultsHere, we study the activation of TF in primary macrophages by a combination of pharmacological, genetic, and biochemical approaches. We demonstrate that primed macrophages effectively control TF cell surface activity by receptor internalization. After cell injury, ATP signals through the purinergic receptor P2rx7 induce release of TF

conclusionsThese data show that procoagulant phospholipid exposure is not sufficient and that TF affinity maturation is required to generate prothrombotic microvesicles from a variety of cell types. These findings are significant for understanding TF-initiated thrombosis and should be considered in designing functional microvesicles-based diagnostic approaches.

Indexed as

Blood CoagulationAdenosine TriphosphateADP-Ribosylation Factor 6ADP-Ribosylation FactorsAnimalsCell-Derived MicroparticlesCell Line, TumorFactor VIIaGene Knock-In TechniquesGenotypeHumansIntegrin alpha4Integrin alpha4beta1MacrophagesMice, Inbred C57BLMice, TransgenicAdenosine TriphosphateADP-Ribosylation Factor 6ADP-Ribosylation FactorsARF6 protein, humanArf6 protein, mouseFactor VIIaIntegrin alpha4Integrin alpha4beta1P2RX7 protein, humanP2rx7 protein, mousePhospholipidsReceptors, Purinergic P2X7Thromboplastindynaminsextracellular vesiclesfibrinmacrophagesproteome

Identifiers

PMID28495929
PMCPMC5501484
OpenAlexW2893616231

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.