ArticleJournal of applied physiology (Bethesda, Md. : 1985)2017
Physical activity modulates corticospinal excitability of the lower limb in young and old adults.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Age-Related Differences in Corticospinal Function and Muscle Strength: A Systematic Review and Meta-Analysis.The European journal of neuroscience · 2026Pooled it
- Neural Plasticity in Spinal and Corticospinal Pathways Induced by Balance Training in Neurologically Intact Adults: A Systematic Review.Frontiers in human neuroscience · 2022Pooled it
- Age-related Deficits in Voluntary Activation: A Systematic Review and Meta-analysis.Medicine and science in sports and exercise · 2020Pooled it
- Pooled it
- Translational perspectives on neurophysiological responses and mechanisms in blood flow restriction exercise.Experimental physiology · 2026Review
- Three-dimensional imaging reveals preserved intrinsic contractile function in aging human skeletal muscle fibers.bioRxiv : the preprint server for biology · 2026Article
- Initial contractions of a single-load fatiguing exercise provide a valid assessment of age-related differences in peak power.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Sex-related differences in corticospinal excitability and inhibition of upper and lower limb muscles.European journal of applied physiology · 2026Article
- Myonuclear loss, rather than senescent myonuclei, associates with fiber type-specific atrophy in aging human skeletal muscle.bioRxiv : the preprint server for biology · 2026Article
- Effects of acidosis and inorganic phosphate on CaAmerican journal of physiology. Cell physiology · 2026Article
- Age-related differences in agility are related to both muscle strength and corticospinal tract function.Physiological reports · 2025Article
- Neural and muscular contributions to the age-related differences in peak power of the knee extensors in men and women.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Cortical and spinal responses to short-term strength training and detraining in young and older adults in rectus femoris muscle.European journal of applied physiology · 2024Article
- Neural and muscular contributions to the age-related loss in power of the knee extensors in men and women.bioRxiv : the preprint server for biology · 2023Article
- Use-dependent corticospinal excitability is associated with resilience and physical performance during simulated military operational stress.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Motor cortex plasticity and visuomotor skill learning in upper and lower limbs of endurance-trained cyclists.European journal of applied physiology · 2022Article
- Physical activity, motor performance and skill learning: a focus on primary motor cortex in healthy aging.Experimental brain research · 2021Review
- Characterization of Motor-Evoked Responses Obtained with Transcutaneous Electrical Spinal Stimulation from the Lower-Limb Muscles after Stroke.Brain sciences · 2021Article
- Attenuated activation of knee extensor muscles during fast contractions in older men and women.European journal of applied physiology · 2020Article
- CaAmerican journal of physiology. Cell physiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Aging is associated with reduced neuromuscular function, which may be due in part to altered corticospinal excitability. Regular physical activity (PA) may ameliorate these age-related declines, but the influence of PA on corticospinal excitability is unknown. The purpose of this study was to determine the influence of age, sex, and PA on corticospinal excitability by comparing the stimulus-response curves of motor evoked potentials (MEP) in 28 young (22.4 ± 2.2 yr; 14 women and 14 men) and 50 old adults (70.2 ± 6.1 yr; 22 women and 28 men) who varied in activity levels. Transcranial magnetic stimulation was used to elicit MEPs in the active vastus lateralis muscle (10% maximal voluntary contraction) with 5% increments in stimulator intensity until the maximum MEP amplitude. Stimulus-response curves of MEP amplitudes were fit with a four-parameter sigmoidal curve and the maximal slope calculated (slope
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.