Trial reportStroke2017
Genetic Drivers of von Willebrand Factor Levels in an Ischemic Stroke Population and Association With Risk for Recurrent Stroke.
Open access · bronzeAbstract readRandomized Controlled Trial
In one paragraph
Trial report in Stroke, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Factors associated with aggregate formation in cold-stored platelets.Vox sanguinis · 2026Article
- Identification of potential biological biomarkers for acute ischemic stroke based on integrated bioinformatics analyses.BMC neurology · 2026Article
- Altered DNA methylation of the ABO gene is associated with differential plasma levels of von willebrand factor and E-selectin.Transfusion · 2025Article
- Von Willebrand Factor Antigen Levels Predict Poor Outcomes in Patients With Stroke and Cancer: Findings From the Multicenter, Prospective, Observational SCAN Study.Journal of the American Heart Association · 2024Article
- Biomarkers for Transient Ischemic Attack: A Brief Perspective of Current Reports and Future Horizons.Journal of clinical medicine · 2022Review
- Applying Machine Learning to Carotid Sonographic Features for Recurrent Stroke in Patients With Acute Stroke.Frontiers in cardiovascular medicine · 2022Article
- The aptamer BT200 blocks von Willebrand factor and platelet function in blood of stroke patients.Scientific reports · 2021Article
- GWAS-linked hot loci predict short-term functional outcome and recurrence of ischemic stroke in Chinese population.American journal of translational research · 2021Article
- Implication of MicroRNA503 in Brain Endothelial Cell Function and Ischemic Stroke.Translational stroke research · 2020Article
- Multifaceted role of glycosylation in transfusion medicine, platelets, and red blood cells.Journal of thrombosis and haemostasis : JTH · 2020Review
- iFunMed: Integrative functional mediation analysis of GWAS and eQTL studies.Genetic epidemiology · 2019Article
- von Willebrand Factor and Platelet Glycoprotein Ib: A Thromboinflammatory Axis in Stroke.Frontiers in immunology · 2019Review
- miR-129-2-3p directly targets SYK gene and associates with the risk of ischaemic stroke in a Chinese population.Journal of cellular and molecular medicine · 2019Article
- ABO blood group polymorphism has an impact on prostate, kidney and bladder cancer in association with longevity.Oncology letters · 2018Article
- Targeting von Willebrand Factor in Ischaemic Stroke: Focus on Clinical Evidence.Thrombosis and haemostasis · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Stephen R WilliamsFrom the Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC (F.C.H.); Department of Public Health Sciences (W.M.C., A.M.S., S.S.R., B.B.W., M.M.S.), Department of Neurology (S.R.W., A.M.S., B.B.W.), and Center for Public Health Genomics (W.M.C., S.S.R., B.B.W., M.M.S.), University of Virginia, Charlottesville; Department of Biology (K.L.K.) and Center for Health Disparities (K.L.K.), East Carolina University, Greenville, NC; Department of Clinical Laboratory Sciences, University of Cape Town, South Africa (G.D.); Division of Nutritional Sciences, University of Illinois at Urbana-Champaign (J.L.R.); and Rhode Island Hospital and the Alpert Medical School, Brown University, Providence (K.L.F.).
Fang-Chi HsuFrom the Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC (F.C.H.); Department of Public Health Sciences (W.M.C., A.M.S., S.S.R., B.B.W., M.M.S.), Department of Neurology (S.R.W., A.M.S., B.B.W.), and Center for Public Health Genomics (W.M.C., S.S.R., B.B.W., M.M.S.), University of Virginia, Charlottesville; Department of Biology (K.L.K.) and Center for Health Disparities (K.L.K.), East Carolina University, Greenville, NC; Department of Clinical Laboratory Sciences, University of Cape Town, South Africa (G.D.); Division of Nutritional Sciences, University of Illinois at Urbana-Champaign (J.L.R.); and Rhode Island Hospital and the Alpert Medical School, Brown University, Providence (K.L.F.).
Keith L KeeneFrom the Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC (F.C.H.); Department of Public Health Sciences (W.M.C., A.M.S., S.S.R., B.B.W., M.M.S.), Department of Neurology (S.R.W., A.M.S., B.B.W.), and Center for Public Health Genomics (W.M.C., S.S.R., B.B.W., M.M.S.), University of Virginia, Charlottesville; Department of Biology (K.L.K.) and Center for Health Disparities (K.L.K.), East Carolina University, Greenville, NC; Department of Clinical Laboratory Sciences, University of Cape Town, South Africa (G.D.); Division of Nutritional Sciences, University of Illinois at Urbana-Champaign (J.L.R.); and Rhode Island Hospital and the Alpert Medical School, Brown University, Providence (K.L.F.).
Wei-Min ChenFrom the Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC (F.C.H.); Department of Public Health Sciences (W.M.C., A.M.S., S.S.R., B.B.W., M.M.S.), Department of Neurology (S.R.W., A.M.S., B.B.W.), and Center for Public Health Genomics (W.M.C., S.S.R., B.B.W., M.M.S.), University of Virginia, Charlottesville; Department of Biology (K.L.K.) and Center for Health Disparities (K.L.K.), East Carolina University, Greenville, NC; Department of Clinical Laboratory Sciences, University of Cape Town, South Africa (G.D.); Division of Nutritional Sciences, University of Illinois at Urbana-Champaign (J.L.R.); and Rhode Island Hospital and the Alpert Medical School, Brown University, Providence (K.L.F.).
Godfrey DzhivhuhoFrom the Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC (F.C.H.); Department of Public Health Sciences (W.M.C., A.M.S., S.S.R., B.B.W., M.M.S.), Department of Neurology (S.R.W., A.M.S., B.B.W.), and Center for Public Health Genomics (W.M.C., S.S.R., B.B.W., M.M.S.), University of Virginia, Charlottesville; Department of Biology (K.L.K.) and Center for Health Disparities (K.L.K.), East Carolina University, Greenville, NC; Department of Clinical Laboratory Sciences, University of Cape Town, South Africa (G.D.); Division of Nutritional Sciences, University of Illinois at Urbana-Champaign (J.L.R.); and Rhode Island Hospital and the Alpert Medical School, Brown University, Providence (K.L.F.).
Joe L RowlesFrom the Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC (F.C.H.); Department of Public Health Sciences (W.M.C., A.M.S., S.S.R., B.B.W., M.M.S.), Department of Neurology (S.R.W., A.M.S., B.B.W.), and Center for Public Health Genomics (W.M.C., S.S.R., B.B.W., M.M.S.), University of Virginia, Charlottesville; Department of Biology (K.L.K.) and Center for Health Disparities (K.L.K.), East Carolina University, Greenville, NC; Department of Clinical Laboratory Sciences, University of Cape Town, South Africa (G.D.); Division of Nutritional Sciences, University of Illinois at Urbana-Champaign (J.L.R.); and Rhode Island Hospital and the Alpert Medical School, Brown University, Providence (K.L.F.).
Andrew M SoutherlandFrom the Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC (F.C.H.); Department of Public Health Sciences (W.M.C., A.M.S., S.S.R., B.B.W., M.M.S.), Department of Neurology (S.R.W., A.M.S., B.B.W.), and Center for Public Health Genomics (W.M.C., S.S.R., B.B.W., M.M.S.), University of Virginia, Charlottesville; Department of Biology (K.L.K.) and Center for Health Disparities (K.L.K.), East Carolina University, Greenville, NC; Department of Clinical Laboratory Sciences, University of Cape Town, South Africa (G.D.); Division of Nutritional Sciences, University of Illinois at Urbana-Champaign (J.L.R.); and Rhode Island Hospital and the Alpert Medical School, Brown University, Providence (K.L.F.).
Karen L FurieFrom the Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC (F.C.H.); Department of Public Health Sciences (W.M.C., A.M.S., S.S.R., B.B.W., M.M.S.), Department of Neurology (S.R.W., A.M.S., B.B.W.), and Center for Public Health Genomics (W.M.C., S.S.R., B.B.W., M.M.S.), University of Virginia, Charlottesville; Department of Biology (K.L.K.) and Center for Health Disparities (K.L.K.), East Carolina University, Greenville, NC; Department of Clinical Laboratory Sciences, University of Cape Town, South Africa (G.D.); Division of Nutritional Sciences, University of Illinois at Urbana-Champaign (J.L.R.); and Rhode Island Hospital and the Alpert Medical School, Brown University, Providence (K.L.F.).
Stephen S RichFrom the Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC (F.C.H.); Department of Public Health Sciences (W.M.C., A.M.S., S.S.R., B.B.W., M.M.S.), Department of Neurology (S.R.W., A.M.S., B.B.W.), and Center for Public Health Genomics (W.M.C., S.S.R., B.B.W., M.M.S.), University of Virginia, Charlottesville; Department of Biology (K.L.K.) and Center for Health Disparities (K.L.K.), East Carolina University, Greenville, NC; Department of Clinical Laboratory Sciences, University of Cape Town, South Africa (G.D.); Division of Nutritional Sciences, University of Illinois at Urbana-Champaign (J.L.R.); and Rhode Island Hospital and the Alpert Medical School, Brown University, Providence (K.L.F.).
Bradford B WorrallFrom the Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC (F.C.H.); Department of Public Health Sciences (W.M.C., A.M.S., S.S.R., B.B.W., M.M.S.), Department of Neurology (S.R.W., A.M.S., B.B.W.), and Center for Public Health Genomics (W.M.C., S.S.R., B.B.W., M.M.S.), University of Virginia, Charlottesville; Department of Biology (K.L.K.) and Center for Health Disparities (K.L.K.), East Carolina University, Greenville, NC; Department of Clinical Laboratory Sciences, University of Cape Town, South Africa (G.D.); Division of Nutritional Sciences, University of Illinois at Urbana-Champaign (J.L.R.); and Rhode Island Hospital and the Alpert Medical School, Brown University, Providence (K.L.F.).
Michèle M SaleFrom the Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC (F.C.H.); Department of Public Health Sciences (W.M.C., A.M.S., S.S.R., B.B.W., M.M.S.), Department of Neurology (S.R.W., A.M.S., B.B.W.), and Center for Public Health Genomics (W.M.C., S.S.R., B.B.W., M.M.S.), University of Virginia, Charlottesville; Department of Biology (K.L.K.) and Center for Health Disparities (K.L.K.), East Carolina University, Greenville, NC; Department of Clinical Laboratory Sciences, University of Cape Town, South Africa (G.D.); Division of Nutritional Sciences, University of Illinois at Urbana-Champaign (J.L.R.); and Rhode Island Hospital and the Alpert Medical School, Brown University, Providence (K.L.F.). msale@virginia.edu.
GARNET (The Genomics and Randomized Trials Network) Collaborative Research Group
University of Cape Town · ZAUniversity of Illinois Urbana-Champaign · USEast Carolina University · USWake Forest University · US
Funding
Pharmacogenomic studies in VISP: results & implications for clinical trial designU01HG005160 · NHGRI · UNIVERSITY OF VIRGINIA · PI SALE, MICHELE M, WORRALL, BRADFORD B · 2009 to 2011
$1.9MShort-Term Training to Increase Diversity in Health-Related ResearchR25HL088724 · NHLBI · UNIVERSITY OF VIRGINIA · PI HALME, ADRIAN J, OWENS, GARY K · 2007 to 2022
$1.8MNHGRI NIH HHS U01 HG005160NHLBI NIH HHS R25 HL088724
Abstract
background and purposevon Willebrand factor (vWF) plays an important role in thrombus formation during cerebrovascular damage. We sought to investigate the potential role of circulating vWF in recurrent cerebrovascular events and identify genetic contributors to variation in vWF level in an ischemic stroke population.
methodsWe analyzed the effect of circulating vWF on risk of recurrent stroke using survival models in the VISP trial (Vitamin Intervention for Stroke Prevention) and the use of vWF in reclassification over traditional factors. We conducted a genome-wide association study) with imputation, based on 1000 Genomes Project data, for circulating vWF levels and then interrogated loci previously associated with vWF levels. We performed expression quantitative trait locus analysis for vWF across different tissues.
resultsElevated vWF levels were associated with increased risk for recurrent stroke in VISP. Adding vWF to traditional clinical parameters also improved recurrent stroke risk prediction. We identified single-nucleotide polymorphisms significantly associated with circulating vWF at the
conclusionsElevated vWF levels are associated with recurrent stroke in VISP. In the VISP population, genetic determinants of vWF levels that impact
Indexed as
AgedAged, 80 and overBrain IschemiaFemaleGene ExpressionGenome-Wide Association StudyHumansMaleMiddle AgedPolymorphism, Single NucleotideQuantitative Trait LociRecurrenceRiskStrokevon Willebrand Factorvon Willebrand Factordecision makinggenetic association studiesriskstrokevitaminsvon Willebrand factor
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.