Evidence map›Paper›PMID 28495802›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2017

A common NHE3 single-nucleotide polymorphism has normal function and sensitivity to regulatory ligands.

Jianyi Yin, Chung-Ming Tse, Boyoung Cha, Rafiquel Sarker, Xinjun C Zhu, Anna Walentinsson, Peter J Greasley, Mark Donowitz

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Jianyi YinDepartment of Medicine, Division of Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Chung-Ming TseDepartment of Medicine, Division of Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Boyoung ChaDepartment of Medicine, Division of Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Rafiquel SarkerDepartment of Medicine, Division of Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Xinjun C ZhuDepartment of Medicine, Division of Gastroenterology and Hepatology, Albany Medical College, Albany, New York; and.
Anna WalentinssonAstraZeneca Gothenburg, Mölndal, Sweden.
Peter J GreasleyAstraZeneca Gothenburg, Mölndal, Sweden.
Mark DonowitzDepartment of Medicine, Division of Gastroenterology, Johns Hopkins University School of Medicine, Baltimore, Maryland; mdonowit@jhmi.edu.
Johns Hopkins Medicine · USAstraZeneca (Sweden) · SEJohns Hopkins University · USAlbany Medical Center Hospital · US

Funding

Two-Photon Microscopy Imaging CoreP01DK072084 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DONOWITZ, MARK · 2006 to 2013
$12.7M
Translational Research Enhancement CoreP30DK089502 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI ZACHOS, NICHOLAS CONSTANTINE · 2011 to 2020
$12.0M
Translational Approaches to Develop Drug Therapy for DiarrheaR24DK099803 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DONOWITZ, MARK · 2014 to 2019
$8.9M
DIARRHEAL DISEASES: A PHYSIOLOGIC APPROACH TO TREATMENTR01DK026523 · NIDDK · TUFTS MEDICAL CENTER · PI DONOWITZ, MARK · 1986 to 2016
$7.8M
PDZ Domain Proteins and NHE3 RegulationR01DK061765 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DONOWITZ, MARK, TSE, CHUNG-MING · 2004 to 2013
$4.7M
NIDDK NIH HHS P01 DK072084NIDDK NIH HHS P30 DK089502NIDDK NIH HHS R01 DK026523NIDDK NIH HHS R01 DK061765NIDDK NIH HHS R24 DK099803
6 · The paper itself

Abstract

Na

Indexed as

AllelesGene FrequencyPolymorphism, Single NucleotideAsian PeopleCardiovascular DiseasesComputational BiologyGenotypeHumansKidney DiseasesMutationSodium-Hydrogen Exchanger 3Sodium-Hydrogen ExchangersWhite PeopleSLC9A3 protein, humanSodium-Hydrogen Exchanger 3Sodium-Hydrogen ExchangersdiarrheaNHE3phenotypepolymorphismSNP

Identifiers

PMID28495802
PMCPMC5582881
OpenAlexW2612125974

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.