Evidence map›Paper›PMID 28495796›Full record

ArticleMolecular biology of the cell2017

Phosphorylation of NHE3-S

Rafiquel Sarker, Boyoung Cha, Olga Kovbasnjuk, Robert Cole, Sandra Gabelli, Chung Ming Tse, Mark Donowitz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology of the cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Proximal renal tubular acidosis with and without Fanconi syndrome.Kidney research and clinical practice · 2019
    Review
  6. Renal Tubular Acidosis: HAdvances in chronic kidney disease · 2018
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Rafiquel SarkerDepartment of Physiology and Department of Medicine, GI Division, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Boyoung ChaDepartment of Physiology and Department of Medicine, GI Division, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Olga KovbasnjukDepartment of Physiology and Department of Medicine, GI Division, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Robert ColeDepartment of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Sandra GabelliDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Chung Ming TseDepartment of Physiology and Department of Medicine, GI Division, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Mark DonowitzDepartment of Physiology and Department of Medicine, GI Division, Johns Hopkins University School of Medicine, Baltimore, MD 21205 mdonowit@jhmi.edu.
Johns Hopkins University · US

Funding

Two-Photon Microscopy Imaging CoreP01DK072084 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DONOWITZ, MARK · 2006 to 2013
$12.7M
Translational Research Enhancement CoreP30DK089502 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI ZACHOS, NICHOLAS CONSTANTINE · 2011 to 2020
$12.0M
Translational Approaches to Develop Drug Therapy for DiarrheaR24DK099803 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DONOWITZ, MARK · 2014 to 2019
$8.9M
DIARRHEAL DISEASES: A PHYSIOLOGIC APPROACH TO TREATMENTR01DK026523 · NIDDK · TUFTS MEDICAL CENTER · PI DONOWITZ, MARK · 1986 to 2016
$7.8M
PDZ Domain Proteins and NHE3 RegulationR01DK061765 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI DONOWITZ, MARK, TSE, CHUNG-MING · 2004 to 2013
$4.7M
NIDDK NIH HHS P01 DK072084NIDDK NIH HHS P30 DK089502NIDDK NIH HHS R01 DK026523NIDDK NIH HHS R01 DK061765NIDDK NIH HHS R24 DK099803
6 · The paper itself

Abstract

Casein kinase 2 (CK2) binds to the NHE3 C-terminus and constitutively phosphorylates a downstream site (S719) that accounts for 40% of basal NHE3 activity. The role of CK2 in regulation of NHE3 activity in polarized Caco-2/bbe cells was further examined by mutation of NHE3-S

Indexed as

Caco-2 CellsCalciumCarbacholCasein Kinase IIEpithelial CellsExocytosisHumansLysophospholipidsPhosphatidylinositol 3-KinasesPhosphoproteinsPhosphorylationProtein BindingProtein DomainsProtein TransportProto-Oncogene Proteins c-aktSignal TransductionCalciumCarbacholCasein Kinase IIlysophosphatidic acidLysophospholipidsPhosphatidylinositol 3-KinasesPhosphoproteinsProto-Oncogene Proteins c-aktSLC9A3 protein, humanSodiumSodium-Hydrogen Exchanger 3sodium-hydrogen exchanger regulatory factorSodium-Hydrogen Exchangers

Identifiers

PMID28495796
PMCPMC5491184
OpenAlexW2613848364

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.