ArticleScience (New York, N.Y.)2017
Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals.
Article in Science (New York, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 147 citations in OpenAlex.
- Acidosis, Iron Dyshomeostasis and Inflammatory Injury.International journal of molecular sciences · 2026Review
- Hinokitiol-fueled disks form exclusionary zones in the presence of iron.RSC advances · 2026Article
- Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review).Oncology reports · 2026Review
- Hinokitiol as a Promising Anticancer Agent: Mechanisms of Action, Potential in Combination Therapy, and Overcoming Chemoresistance.Current pharmaceutical design · 2026Review
- Three-component assembly and structure-function relationships of (-)-gukulenin A.Science (New York, N.Y.) · 2025Article
- Ancestral Sequence Reconstruction to Accelerate Non-heme Iron-dependent Biocatalyst Engineering.ACS central science · 2025Article
- Mitochondrial iron transport via MFRN1 is required for erythroid cell cycle progression.Blood advances · 2025Article
- Low Wall Shear Stress Promotes Atheroma via Arterial Iron Accumulation.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Autonomous Switching of Self-Propelled Motion Modes of Hinokitiol-Fueled Elastomer Matrices.Journal of the American Chemical Society · 2025Article
- Coumarin-facilitated iron transport: An IRT1-independent strategy for iron acquisition in Arabidopsis thaliana.Plant communications · 2025Article
- Molecular prosthetics for CFTR designed for anion selectivity outperform amphotericin B in cultured cystic fibrosis airway epithelia.bioRxiv : the preprint server for biology · 2025Article
- A two-pronged approach to inhibit ferroptosis of MSCs caused by the iron overload in postmenopausal osteoporosis and promote osseointegration of titanium implant.Bioactive materials · 2024Article
- Minimizing higher-order aggregation maximizes iron mobilization by small molecules.Nature chemical biology · 2024Article
- Ferroptosis: principles and significance in health and disease.Journal of hematology & oncology · 2024Review
- Iron Absorption: Molecular and Pathophysiological Aspects.Metabolites · 2024Review
- Oral iron therapy: Current concepts and future prospects for improving efficacy and outcomes.British journal of haematology · 2024Review
- Radiolabeling Heme and Porphyrin withMethods in molecular biology (Clifton, N.J.) · 2024Article
- At the dawn of novel aromatics: "On the Synthesis of Hinokitiol" by Tetsuo Nozoe et al.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2023Article
- Inflammation alters iron distribution in bone and spleen in mice.Metallomics : integrated biometal science · 2023Article
- Cooperative contributions of the klf1 and klf17 genes in zebrafish primitive erythropoiesis.Scientific reports · 2023Article
13 more citing papers are in PubMed but not listed here.
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Authors and funding
21 authors at 5 institutions in 1 country.
Funding
Abstract
Multiple human diseases ensue from a hereditary or acquired deficiency of iron-transporting protein function that diminishes transmembrane iron flux in distinct sites and directions. Because other iron-transport proteins remain active, labile iron gradients build up across the corresponding protein-deficient membranes. Here we report that a small-molecule natural product, hinokitiol, can harness such gradients to restore iron transport into, within, and/or out of cells. The same compound promotes gut iron absorption in DMT1-deficient rats and ferroportin-deficient mice, as well as hemoglobinization in DMT1- and mitoferrin-deficient zebrafish. These findings illuminate a general mechanistic framework for small molecule-mediated site- and direction-selective restoration of iron transport. They also suggest that small molecules that partially mimic the function of missing protein transporters of iron, and possibly other ions, may have potential in treating human diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.