ArticleRespiratory physiology & neurobiology2017
Effect of chronic heart failure in older rats on respiratory muscle and hindlimb blood flow during submaximal exercise.
Article in Respiratory physiology & neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 27 citations in OpenAlex.
- Obligatory neural feedback control of exercise cardiorespiratory function and performance.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Review
- Oxygen transport across the lifespan of male Sprague Dawley rats.Biogerontology · 2025Article
- Consequences of group III/IV afferent feedback and respiratory muscle work on exercise tolerance in heart failure with reduced ejection fraction.Experimental physiology · 2023Review
- Effects of comorbid type II diabetes mellitus and heart failure on rat hindlimb and respiratory muscle blood flow during treadmill exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Influence of locomotor muscle group III/IV afferents on cardiovascular and ventilatory responses in human heart failure during submaximal exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Exercise training decreases intercostal and transversus abdominis muscle blood flows in heart failure rats during submaximal exercise.Respiratory physiology & neurobiology · 2021Article
- Angiotensin converting enzyme inhibition improves cerebrovascular control during exercise in male rats with heart failure.Respiratory physiology & neurobiology · 2021Article
- Differential effects of right and left heart failure on skeletal muscle in rats.Journal of cachexia, sarcopenia and muscle · 2020Article
- Type II diabetes accentuates diaphragm blood flow increases during submaximal exercise in the rat.Respiratory physiology & neurobiology · 2020Article
- Respiratory muscle work influences locomotor convective and diffusive oxygen transport in human heart failure during exercise.Physiological reports · 2020Article
- Combined influence of inspiratory loading and locomotor subsystolic cuff inflation on cardiovascular responses during submaximal exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- High-Intensity Interval Training in Cardiac Rehabilitation.Clinics in geriatric medicine · 2019Review
- Central and peripheral factors mechanistically linked to exercise intolerance in heart failure with reduced ejection fraction.American journal of physiology. Heart and circulatory physiology · 2019Article
- Respiratory Determinants of Exercise Limitation: Focus on Phrenic Afferents and the Lung Vasculature.Clinics in chest medicine · 2019Review
- Exercise Ventilatory Efficiency in Older and Younger Heart Failure Patients With Preserved Ejection Fraction.Journal of cardiac failure · 2019Article
- Exercise ventilatory inefficiency in heart failure and chronic obstructive pulmonary disease.International journal of cardiology · 2019Article
- Ventilatory constraints influence physiological dead space in heart failure.Experimental physiology · 2019Article
- Competition for blood flow distribution between respiratory and locomotor muscles: implications for muscle fatigue.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Review
- Resistive and elastic work of breathing in older and younger adults during exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Dietary nitrate supplementation opposes the elevated diaphragm blood flow in chronic heart failure during submaximal exercise.Respiratory physiology & neurobiology · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Submaximal exercise diaphragm blood flow (BF) is elevated in young chronic heart failure (CHF) rats, while it is unknown if this occurs in older animals. Respiratory and hindlimb muscle BFs (radiolabeled microspheres) were measured at rest and during submaximal exercise (20m/min, 5% grade) in older healthy (n=7) and CHF (n=6) Fischer 344X Brown Norway rats (27-29 mo old). Older CHF, compared to healthy, rats had greater (p<0.01) left ventricular end-diastolic pressure and right ventricle and lung weight (normalized to body weight). During submaximal exercise, respiratory and hindlimb muscle BFs increased (p<0.02) in both groups, while diaphragm BF was higher (CHF: 257±32; healthy: 121±9mL/min/100g, p<0.01) and hindlimb BF lower (CHF: 111±10; healthy: 133±12mL/min/100g, p=0.04) in older CHF compared to healthy rats. Submaximal exercise hindlimb BF was negatively related (r=-0.93; p=0.03) to diaphragm BF in older CHF rats. During submaximal exercise, diaphragm BF is elevated in older CHF compared to healthy rats in proportion to the compromised hindlimb BF.
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