ArticleSchizophrenia research2018
The value of novelty in schizophrenia.
Article in Schizophrenia research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A review on exploration-exploitation trade-off in psychiatric disorders.BMC psychiatry · 2025Pooled it
- FOXG1 Transcriptionally Orchestrates ParvalbuminNeuroscience bulletin · 2026Article
- Automated Behavioral Analysis of Schizophrenia-like Phenotypes in Repeated MK-801-Treated Mice Using IntelliCage.International journal of molecular sciences · 2025Article
- Computational modeling of reversal learning impairments in schizophrenia and bipolar disorder reveals shared failure to exploit rewards.Journal of psychopathology and clinical science · 2025Article
- Novelty triggers time-dependent theta oscillatory dynamics in cortical-hippocampal-midbrain circuitry.Molecular brain · 2024Article
- Reviewing explore/exploit decision-making as a transdiagnostic target for psychosis, depression, and anxiety.Cognitive, affective & behavioral neuroscience · 2024Review
- Motor System-Dependent Effects of Amygdala and Ventral Striatum Lesions on Explore-Exploit Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Reduction in the activity of VTA/SNc dopaminergic neurons underlies aging-related decline in novelty seeking.Communications biology · 2023Article
- Modulation of ventromedial orbitofrontal cortical glutamatergic activity affects the explore-exploit balance and influences value-based decision-making.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Independent and interacting value systems for reward and information in the human brain.eLife · 2022Article
- A review of risky decision-making in psychosis-spectrum disorders.Clinical psychology review · 2022Review
- Increased random exploration in schizophrenia is associated with inflammation.NPJ schizophrenia · 2021Article
- Midbrain circuits of novelty processing.Neurobiology of learning and memory · 2020Review
- Cognition and Reward Circuits in Schizophrenia: Synergistic, Not Separate.Biological psychiatry · 2020Review
- Test-retest reliability of computational parameters versus manifest behavior for decisional flexibility in psychosis.Psychological assessmentArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Influential models of schizophrenia suggest that patients experience incoming stimuli as excessively novel and motivating, with important consequences for hallucinatory experience and delusional belief. However, whether schizophrenia patients exhibit excessive novelty value and whether this interferes with adaptive behaviour has not yet been formally tested. Here, we employed a three-armed bandit task to investigate this hypothesis. Schizophrenia patients and healthy controls were first familiarised with a group of images and then asked to repeatedly choose between familiar and unfamiliar images associated with different monetary reward probabilities. By fitting a reinforcement-learning model we were able to estimate the values attributed to familiar and unfamiliar images when first presented in the context of the decision-making task. In line with our hypothesis, we found increased preference for newly introduced images (irrespective of whether these were familiar or unfamiliar) in patients compared to healthy controls and this to correlate with severity of hallucinatory experience. In addition, we found a correlation between value assigned to novel images and task performance, suggesting that excessive novelty value may interfere with optimal learning in patients, putatively through the disruption of the mechanisms regulating exploration versus exploitation. Our results suggest excessive novelty value in patients, whereby even previously seen stimuli acquire higher value as the result of their exposure in a novel context - a form of 'hyper novelty' which may explain why patients are often attracted by familiar stimuli experienced as new.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.