Evidence map›Paper›PMID 28495070›Full record

SynthesisTransplantation reviews (Orlando, Fla.)2018

Is social support associated with post-transplant medication adherence and outcomes? A systematic review and meta-analysis.

Keren Ladin, Alexis Daniels, Mikala Osani, Raveendhara R Bannuru

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Transplantation reviews (Orlando, Fla.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Article
  3. Article
  4. Article
  5. Psychosocial challenges with transplantation.Current opinion in pulmonary medicine · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Material economic hardships are associated with adverse 1-year outcomes after pediatric liver transplantation: Prospective cohort results from the multicenter SOCIAL-Tx Study.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2025
    Observational
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Keren LadinDepartment of Occupational Therapy, Tufts University, Medford, MA; Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA; Research on Ethics, Aging, and Community Health (REACH Lab). Electronic address: keren.ladin@tufts.edu.
Alexis DanielsDepartment of Occupational Therapy, Tufts University, Medford, MA; Research on Ethics, Aging, and Community Health (REACH Lab).
Mikala OsaniCenter for Treatment Comparison and Integrative Analysis (CTCIA), Tufts Medical Center, Boston, MA.
Raveendhara R BannuruCenter for Treatment Comparison and Integrative Analysis (CTCIA), Tufts Medical Center, Boston, MA.

Funding

Tufts Clinical and Translational Research InstituteKL2TR001063 · NCATS · TUFTS UNIVERSITY BOSTON · PI SELKER, HARRY P. · 2013 to 2017
$2.1M
Comparative effectiveness of mind-body interventions for osteoarthritis - individual patient data network meta-analysisK23AT009374 · NCCIH · TUFTS MEDICAL CENTER · PI BANNURU, RAVEENDHARA REDDY · 2017 to 2021
$830k
NCATS NIH HHS KL2 TR001063NCCIH NIH HHS K23 AT009374
6 · The paper itself

Abstract

Although social support is used to determine transplant eligibility, the relationship between social support, medication adherence, and survival among transplant recipients remains unclear. We estimated the relationship between social support and post-transplant medication adherence and outcomes using 10 electronic databases from inception to January 2016. Study quality was assessed and all review stages were conducted independently by 2 reviewers. Systematic review and meta-analysis were conducted. Thirty-two studies (9102 participants) met inclusion criteria: 21 assessed medication adherence (5197 participants), and 13 assessed clinical outcomes (3905 participants). Among high quality studies, neither social support nor marital status was predictive of medication adherence or post-transplant outcomes. Social support was not associated with medication adherence. It was associated with superior post-transplant outcomes, but the relationship was not significant among high quality studies. Compared to unmarried recipients, married recipients were more likely to adhere to medication post-transplant, but this relationship was not significant among high quality studies. Marital status was not significantly associated with transplant success. Social support is weakly and inconsistently associated with post-transplant adherence and outcomes. Larger prospective studies using consistent and validated measures are needed to justify the use of inadequate social support as a contraindication to transplantation.

Indexed as

Kidney TransplantationMedication AdherenceSocial SupportGraft RejectionHumansTransplant Recipients

Identifiers

PMID28495070
PMCPMC5658266

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.