ArticleJournal of the American College of Cardiology2017
Prognostic Implications of Moderate Aortic Stenosis in Patients With Left Ventricular Systolic Dysfunction.
Article in Journal of the American College of Cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Moderate Aortic Valve Stenosis Is Associated With Increased Mortality Rate and Lifetime Loss: Systematic Review and Meta-Analysis of Reconstructed Time-to-Event Data of 409 680 Patients.Journal of the American Heart Association · 2024Pooled it
- Echocardiographic Imaging Challenges in Obesity: Guideline Recommendations and Limitations of Adjusting to Body Size.Journal of the American Heart Association · 2020Guideline
- Article
- Transcatheter aortic valve implantation for symptomatic severe aortic stenosis and its expanding clinical indications.The Korean journal of internal medicine · 2026Review
- Ischemic vs. Nonischemic Cardiomyopathy in TAVR for Moderate Aortic Stenosis: A TAVR UNLOAD Sub Analysis.Structural heart : the journal of the Heart Team · 2026Article
- Interplay between medical and interventional therapies in valvular heart disease and heart failure: an expert opinion paper.ESC heart failure · 2026Review
- Clinical, Echocardiographic, and Socioeconomic Predictors of Progression and Outcomes in Patients With Moderate Aortic Stenosis.Echocardiography (Mount Kisco, N.Y.) · 2025Article
- Evaluation of 4D Flow MRI-Derived Aortic Hemodynamics and Their Relationships With Left Ventricular Remodeling in Patients With Moderate Aortic Stenosis: A Preliminary Study.Echocardiography (Mount Kisco, N.Y.) · 2025Article
- Prognostic and therapeutic implications of a low aortic valve calcium score in patients with low-gradient aortic stenosis.European heart journal. Cardiovascular Imaging · 2025Article
- Moderate Aortic Stenosis With Cardiac Damage: A New Type of Severe Aortic Stenosis.Structural heart : the journal of the Heart Team · 2024Review
- Moderate Aortic Stenosis-Advanced Imaging, Risk Assessment, and Treatment Strategies.Structural heart : the journal of the Heart Team · 2024Review
- Prevalence, Characteristics, and Impact on Prognosis of Aortic Stenosis in Patients With Cardiac Amyloidosis.Journal of the American Heart Association · 2024Article
- Unraveling the Enigma of Moderate Aortic Stenosis: Challenges and Future Prospects.Journal of clinical medicine · 2024Review
- Role of aortic valve replacement in moderate aortic stenosis: a 10-year outcomes study.Open heart · 2024Article
- The Impact of Acute Heart Failure on Frailty Degree and Outcomes in Elderly Patients with Severe Aortic Stenosis and Chronic Heart Failure with Preserved Ejection Fraction.Journal of cardiovascular development and disease · 2024Article
- Asymptomatic Severe and Moderate Aortic Stenosis: Time for Appraisal of Treatment Indications.Structural heart : the journal of the Heart Team · 2023Review
- An alternative method of indexation in aortic stenosis: height-adjusted effective orifice area : An observational prospective study.Cardiovascular ultrasound · 2023Observational
- Comorbidities and Symptom Status in Moderate and Severe Aortic Stenosis: A Multicenter Clinical Cohort Study.JACC. Advances · 2023Article
- Correlation between artificial intelligence-enabled electrocardiogram and echocardiographic features in aortic stenosis.European heart journal. Digital health · 2023Article
- Transcatheter Aortic Valve Replacement in Patients With Reduced Ejection Fraction and Nonsevere Aortic Stenosis.Circulation. Cardiovascular interventions · 2023Article
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLeft ventricular (LV) systolic dysfunction and moderate aortic stenosis (AS) are more frequent with advancing age and often coexist. Afterload reduction is the mainstay of pharmacological treatment of heart failure (HF). Aortic valve replacement (AVR) is only formally indicated for symptomatic severe AS.
objectivesThis study sought to determine the clinical outcome of patients with concomitant moderate AS and LV systolic dysfunction.
methodsEchocardiographic and clinical data of patients with moderate AS and LV systolic dysfunction between 2010 and 2015 from 4 large academic institutions were retrospectively analyzed. Moderate AS was defined as aortic valve area between 1.0 and 1.5 cm
resultsA total of 305 patients (mean age 73 ± 11 years; 75% male) were included. The majority were symptomatic at the time of index echocardiogram (New York Heart Association [NYHA] functional class II: 42%; NYHA functional class III: 28%; and NYHA functional class IV: 4%). Ischemic heart disease was present in 72% of patients. At 4-year follow-up, the primary composite endpoint occurred in 61%. The main predictors for the primary endpoint were male sex (p = 0.022), NYHA functional class III or IV (p < 0.001), and peak aortic jet velocity (p < 0.001). The rate of the composite of all-cause death or HF hospitalization was 48%, rate of all-cause death was 36%, and rate of HF hospitalization was 27%. AVR occurred in 24% of patients.
conclusionsPatients with concomitant moderate AS and LV systolic dysfunction are at high risk for clinical events. Further studies are needed to determine if earlier AVR in these patients might improve clinical outcome.
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