ArticleBiophysical journal2017
Microvessel Chaste: An Open Library for Spatial Modeling of Vascularized Tissues.
Article in Biophysical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Exploring the relationship between vascular remodelling and tumour growth using agent-based modelling.PLoS computational biology · 2026Article
- Abnormal vasculature reduces overlap between drugs and oxygen in a tumour computational model: Implications for therapeutic efficacy.PLoS computational biology · 2025Article
- Analytical and numerical properties of an extended angiogenesis PDEs model.Journal of mathematical biology · 2025Article
- Enhanced perfusion following exposure to radiotherapy: A theoretical investigation.PLoS computational biology · 2024Article
- Seven challenges in the multiscale modeling of multicellular tissues.WIREs mechanisms of disease · 2022Review
- Topological data analysis distinguishes parameter regimes in the Anderson-Chaplain model of angiogenesis.PLoS computational biology · 2021Article
- Comparative analysis of continuum angiogenesis models.Journal of mathematical biology · 2021Article
- Modelling of Epithelial Growth, Fission and Lumen Formation During Embryonic Thyroid Development: A Combination of Computational and Experimental Approaches.Frontiers in endocrinology · 2021Article
- Abnormal morphology biases hematocrit distribution in tumor vasculature and contributes to heterogeneity in tissue oxygenation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Fine-grained simulations of the microenvironment of vascularized tumours.Scientific reports · 2019Article
- Tumorcode : A framework to simulate vascularized tumors.The European physical journal. E, Soft matter · 2018Article
- The importance of geometry in the corneal micropocket angiogenesis assay.PLoS computational biology · 2018Article
- PhysiCell: An open source physics-based cell simulator for 3-D multicellular systems.PLoS computational biology · 2018Article
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Authors and funding
7 authors.
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Abstract
Spatial models of vascularized tissues are widely used in computational physiology. We introduce a software library for composing multiscale, multiphysics models for applications including tumor growth, angiogenesis, osteogenesis, coronary perfusion, and oxygen delivery. Composition of such models is time consuming, with many researchers writing custom software. Recent advances in imaging have produced detailed three-dimensional (3D) datasets of vascularized tissues at the scale of individual cells. To fully exploit such data there is an increasing need for software that allows user-friendly composition of efficient, 3D models of vascularized tissues, and comparison of predictions with in vivo or in vitro experiments and alternative computational formulations. Microvessel Chaste can be used to build simulations of vessel growth and adaptation in response to mechanical and chemical stimuli; intra- and extravascular transport of nutrients, growth factors and drugs; and cell proliferation in complex 3D geometries. In addition, it can be used to develop custom software for integrating modeling with experimental data processing workflows, facilitated by a comprehensive Python interface to solvers implemented in C++. This article links to two reproducible example problems, showing how the library can be used to build simulations of tumor growth and angiogenesis with realistic vessel networks.
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