ArticleCell reports2017
Multiplexed Spike Coding and Adaptation in the Thalamus.
Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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Who cites it
33 citing papers in PubMed, 54 citations in OpenAlex.
- A Reconfigurable Memristive Spiking Neuron Enabling Advanced Neuromorphic Computing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Spinal-inspired artificial tactile interneuron with high-order burst spiking for intelligent edge interfaces.Nature communications · 2026Article
- Corticothalamic layer 6 controls cortical activity and thalamic firing mode in a bidirectional manner.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Simultaneous encoding of sensory features: the role of multiplexing and noise in tactile perception and neural representation.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Thalamus enables active dendritic coupling of inputs arriving at different cortical layers.Nature communications · 2025Article
- Article
- Distinct Disruptions in CA1 and CA3 Place Cell Function in Alzheimer's Disease Mice.bioRxiv : the preprint server for biology · 2024Article
- Spiking activity in the visual thalamus is coupled to pupil dynamics across temporal scales.PLoS biology · 2024Article
- The Associative Thalamus: A Switchboard for Cortical Operations and a Promising Target for Schizophrenia.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Multiplexing intensity and frequency sensations for artificial touch by modulating temporal features of electrical pulse trains.Frontiers in neuroscience · 2024Article
- Stimulus contrast modulates burst activity in the lateral geniculate nucleus.Current research in neurobiology · 2023Article
- Exploring retinal ganglion cells encoding to multi-modal stimulation using 3D microelectrodes arrays.Frontiers in bioengineering and biotechnology · 2023Article
- Robust effects of corticothalamic feedback and behavioral state on movie responses in mouse dLGN.eLife · 2022Article
- Are Grid-Like Representations a Component of All Perception and Cognition?Frontiers in neural circuits · 2022Article
- Neural burst codes disguised as rate codes.Scientific reports · 2021Article
- High-frequency burst spiking in layer 5 thick-tufted pyramids of rat primary somatosensory cortex encodes exploratory touch.Communications biology · 2021Article
- Thalamic state influences timing precision in the thalamocortical circuit.Journal of neurophysiology · 2021Article
- Temporal dynamics of the cerebello-cortical convergence in ventro-lateral motor thalamus.The Journal of physiology · 2021Article
- The Cellular Electrophysiological Properties Underlying Multiplexed Coding in Purkinje Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Corticothalamic Pathways From Layer 5: Emerging Roles in Computation and Pathology.Frontiers in neural circuits · 2021Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
High-frequency "burst" clusters of spikes are a generic output pattern of many neurons. While bursting is a ubiquitous computational feature of different nervous systems across animal species, the encoding of synaptic inputs by bursts is not well understood. We find that bursting neurons in the rodent thalamus employ "multiplexing" to differentially encode low- and high-frequency stimulus features associated with either T-type calcium "low-threshold" or fast sodium spiking events, respectively, and these events adapt differently. Thus, thalamic bursts encode disparate information in three channels: (1) burst size, (2) burst onset time, and (3) precise spike timing within bursts. Strikingly, this latter "intraburst" encoding channel shows millisecond-level feature selectivity and adapts across statistical contexts to maintain stable information encoded per spike. Consequently, calcium events both encode low-frequency stimuli and, in parallel, gate a transient window for high-frequency, adaptive stimulus encoding by sodium spike timing, allowing bursts to efficiently convey fine-scale temporal information.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.