ArticleCritical care (London, England)2017
Association between fluid intake and mortality in critically ill patients with negative fluid balance: a retrospective cohort study.
Article in Critical care (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Trendelenburg maneuver to predict fluid responsiveness in patients under mechanical ventilation with spontaneous breathing: a prospective study.BMC anesthesiology · 2026Article
- The relationship between admission Braden score and poor prognosis in Sepsis patients: evidence from the MIMIC-III database.BMC infectious diseases · 2025Article
- Intraabdominal hypertension is less common than it used to be: A pilot step wedge trial.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2025Article
- Impact of different intravenous bolus rates on fluid and electrolyte balance and mortality in critically ill patients.World journal of critical care medicine · 2024Review
- Article
- Survival prediction for heart failure complicated by sepsis: based on machine learning methods.Frontiers in medicine · 2024Article
- Identification of subphenotypes in critically ill thrombocytopenic patients with different responses to therapeutic interventions: a retrospective study.Frontiers in medicine · 2023Article
- Association between fluid balance and mortality for heart failure and sepsis: a propensity score-matching analysis.BMC anesthesiology · 2022Article
- Association between fluid intake and extubation failure in intensive care unit patients with negative fluid balance: a retrospective observational study.BMC anesthesiology · 2022Observational
- Early Diuretics for De-resuscitation in Septic Patients With Left Ventricular Dysfunction.Clinical Medicine Insights. Cardiology · 2022Article
- Nordic survey on assessment and treatment of fluid overload in intensive care.Frontiers in medicine · 2022Article
- Establishment and Implementation of Potential Fluid Therapy Balance Strategies for ICU Sepsis Patients Based on Reinforcement Learning.Frontiers in medicine · 2022Article
- Circulatory trajectories after out-of-hospital cardiac arrest: a prospective cohort study.BMC anesthesiology · 2021Observational
- Right ventricular dysfunction and right ventricular-arterial uncoupling at admission increase the in-hospital mortality in patients with COVID-19 disease.Echocardiography (Mount Kisco, N.Y.) · 2021Article
- Association between Cumulative Fluid Balance and Outcomes in Acute Respiratory Distress Syndrome Patients Treated with Extracorporeal Membrane Oxygenation.Journal of chest surgery · 2021Article
- The effects of hemodynamic monitoring using the PiCCO system on critically ill patients.American journal of translational research · 2021Article
- Early diuretic use and mortality in critically ill patients with vasopressor support: a propensity score-matching analysis.Critical care (London, England) · 2019Article
- Time-related association between fluid balance and mortality in sepsis patients: interaction between fluid balance and haemodynamics.Scientific reports · 2018Article
- The first 24-h negative fluid balance is related to lower short-term mortality but higher AKI progression in critically ill heart failure: a retrospective cohort study.Therapeutic advances in cardiovascular diseaseArticle
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCompared to positive fluid balance (FB), negative FB is associated with improved clinical outcomes in critically ill patients. However, as to whether achieving more negative FB can further improve outcomes has not been investigated. This study aimed to investigate whether more negative FB and restricted fluid intake were associated with improved outcomes in critically ill patients.
methodData were extracted from the Multi-parameter Intelligent Monitoring in Intensive Care III Database. Patients achieving negative FB at 48 hours after intensive care unit (ICU) admission were screened. The primary outcome was hospital mortality. Logistic models were built to explore the association between FB, fluid intake and mortality, using FB and fluid intake (both four levels) as design variables and using the linear spline function method.
resultsThere were 2068 patients meeting the inclusion criteria. Compared to slight negative FB (level 1), there was a decreased tendency towards mortality with FB level 2 (OR 0.88, 95% CI 0.69-1.11) and level 3 (OR 0.79, 95% CI 0. 65-1.11); however, only extreme negative FB (level 4) was significant (OR 0.56, 95% CI 0. 33-0.95). Fluid intake and urine output were evenly distributed over the first 48 hours after ICU admission. Fluid intake was inversely associated with hospital mortality, with the OR decreased stepwise from level 2 (OR 0.73, 95% CI 0.56-0.96) to level 4 (OR 0.47, 95% CI 0.30-0.74), referred to level 1. Urine output also showed a similar pattern. Diuretic use was associated with higher mortality in both models.
conclusionIn critically ill patients with negative FB, both increased fluid intake and urine output were associated with decreased hospital mortality. However, compared to slight FB, achieving more negative FB was not associated with reduced mortality.
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