ArticleBMC biology2017
Heterosis as a consequence of regulatory incompatibility.
Article in BMC biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
- Gene expression is stable despite widespread cis and trans regulatory divergence inbioRxiv : the preprint server for biology · 2026Article
- Restoration of ancestral transcriptional plasticity contributes to plastic heterosis in fatty liver of hybrid ducks.Communications biology · 2026Article
- Influence of Ploidy and Genetic Background on Stress Tolerance of Intraspecific Yeast Hybrids.Microbial biotechnology · 2026Article
- Asymmetric mitonuclear interactions trigger transgressive inheritance and mitochondria-dependent heterosis in hybrids of the model systemIMA fungus · 2025Article
- Understanding brewing trait inheritance inmSystems · 2024Article
- Comparative Physiological, Proteomic, and Metabolomic Insights into a Promising Low-Pruning Mulberry Cultivar for Silkworm Rearing.International journal of molecular sciences · 2024Article
- Hybrid adaptation is hampered by Haldane's sieve.Nature communications · 2024Article
- Nontraditional models as research tools: the road not taken.Trends in molecular medicine · 2024Review
- Expression patterns ofApplied and environmental microbiology · 2024Article
- The mRNA-lncRNA landscape of multiple tissues uncovers key regulators and molecular pathways that underlie heterosis for feed intake and efficiency in laying chickens.Genetics, selection, evolution : GSE · 2023Article
- Evolutionary and Genomic Diversity of True Polyploidy in Tetrapods.Animals : an open access journal from MDPI · 2023Review
- Protein nonadditive expression and solubility contribute to heterosis inFrontiers in plant science · 2023Article
- Heterosis of fitness and phenotypic variance in the evolution of a diploid gene regulatory network.PNAS nexus · 2022Article
- Joint effects of genes underlying a temperature specialization tradeoff in yeast.PLoS genetics · 2021Article
- Interspecific hybridization as a driver of fungal evolution and adaptation.Nature reviews. Microbiology · 2021Review
- Improved redox homeostasis owing to the up-regulation of one-carbon metabolism and related pathways is crucial for yeast heterosis at high temperature.Genome research · 2021Article
- Interspecific hybrids show a reduced adaptive potential under DNA damaging conditions.Evolutionary applications · 2021Article
- Accumulation of cis- and trans-regulatory variations is associated with phenotypic divergence of a complex trait between yeast species.G3 (Bethesda, Md.) · 2021Article
- Heterosis and Hybrid Crop Breeding: A Multidisciplinary Review.Frontiers in genetics · 2021Review
- Gene Transcription as a Limiting Factor in Protein Production and Cell Growth.G3 (Bethesda, Md.) · 2020Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe merging of genomes in inter-specific hybrids can result in novel phenotypes, including increased growth rate and biomass yield, a phenomenon known as heterosis. Heterosis is typically viewed as the opposite of hybrid incompatibility. In this view, the superior performance of the hybrid is attributed to heterozygote combinations that compensate for deleterious mutations accumulating in each individual genome, or lead to new, over-dominating interactions with improved performance. Still, only fragmented knowledge is available on genes and processes contributing to heterosis.
resultsWe describe a budding yeast hybrid that grows faster than both its parents under different environments. Phenotypically, the hybrid progresses more rapidly through cell cycle checkpoints, relieves the repression of respiration in fast growing conditions, does not slow down its growth when presented with ethanol stress, and shows increased signs of DNA damage. A systematic genetic screen identified hundreds of S. cerevisiae alleles whose deletion reduced growth of the hybrid. These growth-affecting alleles were condition-dependent, and differed greatly from alleles that reduced the growth of the S. cerevisiae parent.
conclusionsOur results define a budding yeast hybrid that is perturbed in multiple regulatory processes but still shows a clear growth heterosis. We propose that heterosis results from incompatibilities that perturb regulatory mechanisms, which evolved to protect cells against damage or prepare them for future challenges by limiting cell growth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.