Evidence map›Paper›PMID 28494767›Full record

ArticleDiagnostic pathology2017

Intestinal differentiated mucinous adenocarcinoma of the endometrium with sporadic MSI high status: a case report.

Mafalda Trippel, Sara Imboden, Andrea Papadia, Michael D Mueller, Nando Mertineit, Kirsi Härmä, Alina Nicolae, Erik Vassella, Tilman T Rau

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostic pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Mafalda TrippelInstitute of Pathology, University of Bern, Murtenstr. 31, 3008, Bern, CH, Switzerland.
Sara ImbodenDepartment of Obstetrics and Gynaecology, Inselspital, University of Bern, Bern, Switzerland.
Andrea PapadiaDepartment of Obstetrics and Gynaecology, Inselspital, University of Bern, Bern, Switzerland.
Michael D MuellerDepartment of Obstetrics and Gynaecology, Inselspital, University of Bern, Bern, Switzerland.
Nando MertineitDepartment of Radiology, Inselspital, University of Bern, Bern, Switzerland.
Kirsi HärmäDepartment of Radiology, Inselspital, University of Bern, Bern, Switzerland.
Alina NicolaeInstitute of Pathology, University of Bern, Murtenstr. 31, 3008, Bern, CH, Switzerland.
Erik VassellaInstitute of Pathology, University of Bern, Murtenstr. 31, 3008, Bern, CH, Switzerland.
Tilman T RauInstitute of Pathology, University of Bern, Murtenstr. 31, 3008, Bern, CH, Switzerland. Tilman.Rau@pathology.unibe.ch.
University of Bern · CHUniversity Hospital of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntestinal differentiation of primary mucinous adenocarcinoma of the uterine corpus is exceedingly rare in comparison to the approximately 25% rate in endocervical and ovarian mucinous carcinoma. Additionally, little is known about the related genetic and epigenetic alterations, even though large-scale molecular characterisation of the different types of endometrial cancer took place in the TCGA project along the entities defined by the recent WHO classification. CASE PRESENTATION: We present a 62-year-old patient harbouring a primary mucinous carcinoma of the uterine corpus with a morphological resemblance to mucinous colorectal adenocarcinoma. The intestinal differentiation was substantiated by CDX2 and CK20 positivity in the absence of PAX8, p16, WT1, p53, ER, PgR, AFP, SALL4 and Glypican3. A high MSI status with MLH1 hypermethylation was revealed by molecular testing.

conclusionIntestinal differentiation of mucinous adenocarcinoma of the endometrium is a unique observation. Besides morphology, it obviously can share molecular features of sporadic MSI colorectal cancers. It can be speculated that either CDX2 positive morula formation or intestinal metaplasia of the endometrium as rare conditions might be the origin of carcinogenesis for this type II endometrial cancer. Both conditions were not detectable in this case. Of note, categorising endometrial cancers in genetic subgroups like MSI high cancers alone might lead to the integration of likewise morphologically different tumours like the case presented here with intestinal differentiation. Hence, careful genotype-phenotype correlations are warranted for studies of mucinous adenocarcinoma of the endometrium.

Indexed as

Cell DifferentiationMicrosatellite InstabilityAdenocarcinoma, MucinousBiomarkers, TumorBiopsyDNA MethylationEndometrial NeoplasmsFemaleGenetic Predisposition to DiseaseHumansImmunohistochemistryMiddle AgedMutL Protein Homolog 1PhenotypePromoter Regions, GeneticTomography, X-Ray ComputedBiomarkers, TumorMLH1 protein, humanMutL Protein Homolog 1Endometrial cancerIntestinal differentiationMLH1 promotor methylationMSIMucinous adenocarcinoma

Identifiers

PMID28494767
PMCPMC5427532
OpenAlexW2612343224

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.