ArticleRespiratory research2017
COPD monocytes demonstrate impaired migratory ability.
Article in Respiratory research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 24 citations in OpenAlex.
- ANT1 Deficiency Impairs Macrophage Metabolism and Migration, Protecting Against Emphysema in Chronic Obstructive Pulmonary Disease.American journal of respiratory cell and molecular biology · 2025Article
- Identification and Experimental Validation of Biomarkers Related to MiR-125a-5p in Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2025Article
- Dual Exposure to E-Cigarette Vapour and Cigarette Smoke Results in Poorer Airway Cell, Monocyte, and Macrophage Function Than Single Exposure.International journal of molecular sciences · 2024Article
- Macrophage Polarization and Functions in Pathogenesis of Chronic Obstructive Pulmonary Disease.International journal of molecular sciences · 2024Review
- Phenotypic Profiling of Immune Cells and Their Mediators in Chronic Obstructive Pulmonary Disease.Biomedicines · 2023Article
- Combining bioinformatics and machine learning to identify common mechanisms and biomarkers of chronic obstructive pulmonary disease and atrial fibrillation.Frontiers in cardiovascular medicine · 2023Article
- Increased L-Selectin on Monocytes Is Linked to the Autoantibody Profile in Systemic Sclerosis.International journal of molecular sciences · 2022Article
- Highway toFrontiers in pharmacology · 2022Review
- Method Matters: Effect of Purification Technology on Neutrophil Phenotype and Function.Frontiers in immunology · 2022Article
- Phenotypical and Functional Characterization of Neutrophils in Two Pyrin-Associated Auto-inflammatory Diseases.Journal of clinical immunology · 2021Article
- Functional and Transcriptional Adaptations of Blood Monocytes Recruited to the Cystic Fibrosis Airway Microenvironment In Vitro.International journal of molecular sciences · 2021Article
- miR-4456/CCL3/CCR5 Pathway in the Pathogenesis of Tight Junction Impairment in Chronic Obstructive Pulmonary Disease.Frontiers in pharmacology · 2021Article
- Lung Macrophage Functional Properties in Chronic Obstructive Pulmonary Disease.International journal of molecular sciences · 2020Review
- Systemic Immuno-metabolic alterations in chronic obstructive pulmonary disease (COPD).Respiratory research · 2019Article
- Chemokines in COPD: From Implication to Therapeutic Use.International journal of molecular sciences · 2019Review
- The monocyte-dependent immune response to bacteria is suppressed in smoking-induced COPD.Journal of molecular medicine (Berlin, Germany) · 2019Article
- Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases.Frontiers in immunology · 2019Review
- Understanding the role of neutrophils in chronic inflammatory airway disease.F1000Research · 2019Review
- Characterisation of lung macrophage subpopulations in COPD patients and controls.Scientific reports · 2017Article
- Neutrophils from Patients with Primary Ciliary Dyskinesia Display Reduced Chemotaxis to CXCR2 Ligands.Frontiers in immunology · 2017Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncreased lung macrophage numbers in COPD may arise from upregulation of blood monocyte recruitment into the lungs. CCR5 is a monocyte chemokine receptor regulated by interleukin-6 (IL-6); the concentration of CCR5 ligands are known to be elevated in COPD lungs. The objective of this study was to investigate mechanisms of monocyte recruitment to the lung in COPD, including the role of CCR5 signalling.
methodsNinety one COPD patients, 29 smokers (S) and 37 non-smokers (NS) underwent sputum induction, plasma sampling (to measure IL-6 and soluble IL-6 receptor [sIL-6R] by immunoassay), monocyte characterization (by flow cytometry) and monocyte isolation for cell migration and quantitative polymerase chain reaction studies. Lung tissue was used for immunohistochemistry.
resultsPlasma IL-6 and sIL-6R levels were increased in COPD. Greater proportions of COPD CD14
conclusionCOPD monocytes show decreased migratory ability despite increased CCR5 expression. Increased COPD lung macrophage numbers may be due to delayed apoptosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.