ArticleJournal of innate immunity2017
The Peptidoglycan Recognition Proteins PGRPLA and PGRPLB Regulate Anopheles Immunity to Bacteria and Affect Infection by Plasmodium.
Article in Journal of innate immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 105 citations in OpenAlex.
- Malaria mosquito antimicrobial defence requires immunity and detoxification gene regulation by Lola.Insect molecular biology · 2026Article
- PGRP-LA regulates peritrophic matrix synthesis and influences trypanosome infection outcomes in tsetse flies.PLoS pathogens · 2026Article
- Changes in the Anopheles arabiensis transcriptome and gut microbiota profiles associated with the endosymbiotic Microsporidia MB.BMC genomics · 2025Article
- A PGRPLC1/Rel2-F axis controls Anopheles gambiae resistance to systemic infections with Gram-positive bacteria containing Lys-type peptidoglycan.PLoS pathogens · 2025Article
- Role of microbiota in host-Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025Review
- Article
- The transcriptional response in mosquitoes distinguishes between fungi and bacteria but not Gram types.BMC genomics · 2024Article
- Article
- Unravelling the genome of the brackish water malaria vector Anopheles aquasalis.Scientific reports · 2023Article
- Microbiota in disease-transmitting vectors.Nature reviews. Microbiology · 2023Review
- Recognition of Arboviruses by the Mosquito Immune System.Biomolecules · 2023Review
- Evolution and assembly ofOpen biology · 2023Article
- Bacterial Microbiota from Lab-Reared and Field-CapturedMicroorganisms · 2023Article
- The immune deficiency and c-Jun N-terminal kinase pathways drive the functional integration of the immune and circulatory systems of mosquitoes.Open biology · 2022Article
- Transcriptional response of individual Hawaiian Culex quinquefasciatus mosquitoes to the avian malaria parasite Plasmodium relictum.Malaria journal · 2022Article
- Insulin-like peptide 3 stimulates hemocytes to proliferate in anautogenous and facultatively autogenous mosquitoes.The Journal of experimental biology · 2022Article
- Microbiota identified from preserved Anopheles.Malaria journal · 2021Article
- Trained Immunity inFrontiers in microbiology · 2021Article
- Mosquito Trilogy: Microbiota, Immunity and Pathogens, and Their Implications for the Control of Disease Transmission.Frontiers in microbiology · 2021Review
- C-type lectin-mediated microbial homeostasis is critical for Helicoverpa armigera larval growth and development.PLoS pathogens · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
Abstract
Peptidoglycan recognition proteins (PGRPs) form a family of immune regulators that is conserved from insects to mammals. In the malaria vector mosquito Anophelescoluzzii, the peptidoglycan receptor PGRPLC activates the immune-deficiency (Imd) pathway limiting both the microbiota load and Plasmodium infection. Here, we carried out an RNA interference screen to examine the role of all 7 Anopheles PGRPs in infections with Plasmodium berghei and P. falciparum. We show that, in addition to PGRPLC, PGRPLA and PGRPS2/PGRPS3 also participate in antiparasitic defenses, and that PGRPLB promotes mosquito permissiveness to P. falciparum. We also demonstrate that following a mosquito blood feeding, which promotes growth of the gut microbiota, PGRPLA and PGRPLB positively and negatively regulate the activation of the Imd pathway, respectively. Our data demonstrate that PGRPs are important regulators of the mosquito epithelial immunity and vector competence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.