ArticleCell host & microbe2017
Quorum Sensing Attenuates Virulence in Sodalis praecaptivus.
Article in Cell host & microbe, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 61 citations in OpenAlex.
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- Implementing high-throughput insect barcoding in microbiome studies: impact of non-destructive DNA extraction on microbiome reconstruction.bioRxiv : the preprint server for biology · 2024Article
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- Variable organization of symbiont-containing tissue across planthoppers hosting different heritable endosymbionts.Frontiers in physiology · 2023Article
- Rational engineering of a synthetic insect-bacterial mutualism.Current biology : CB · 2022Article
- Abundance and Localization of Symbiotic Bacterial Communities in the Fly Parasitoid Spalangia cameroni.Applied and environmental microbiology · 2022Article
- Incipient genome erosion and metabolic streamlining for antibiotic production in a defensive symbiont.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Vertical Transmission at the Pathogen-Symbiont Interface: Serratia symbiotica and Aphids.mBio · 2021Article
- Genetic Modification ofmSphere · 2021Article
- Ecological Divergence Within the Enterobacterial GenusFrontiers in microbiology · 2021Article
- Infection Patterns and Fitness Effects ofInsects · 2020Article
- Quorum sensing sets the stage for the establishment and vertical transmission of Sodalis praecaptivus in tsetse flies.PLoS genetics · 2020Article
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- Closely Related Male-Killing and Nonmale-Killing Wolbachia Strains in the Oriental Tea Tortrix Homona magnanima.Microbial ecology · 2020Article
- We're in this Together: Sensation of the Host Cell Environment by Endosymbiotic Bacteria.Results and problems in cell differentiation · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Sodalis praecaptivus is a close relative and putative environmental progenitor of the widely distributed, insect-associated, Sodalis-allied symbionts. Here we show that mutant strains of S. praecaptivus that lack genetic components of a quorum-sensing (QS) apparatus have a rapid and potent killing phenotype following microinjection into an insect host. Transcriptomic and genetic analyses indicate that insect killing occurs as a consequence of virulence factors, including insecticidal toxins and enzymes that degrade the insect integument, which are normally repressed by QS at high infection densities. This method of regulation suggests that virulence factors are only utilized in early infection to initiate the insect-bacterial association. Once bacteria reach sufficient density in host tissues, the QS circuit represses expression of these harmful genes, facilitating a long-lasting and benign association. We discuss the implications of the functionality of this QS system in the context of establishment and evolution of mutualistic relationships involving these bacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.