Evidence map›Paper›PMID 28494131›Full record

ArticleThe American journal on addictions2017

Neuropsychological functioning in college students who misuse prescription stimulants.

Timothy E Wilens, Nicholas W Carrellas, MaryKate Martelon, Amy M Yule, Ronna Fried, Rayce Anselmo, Sean Esteban McCabe

Open access · bronzeAbstract read
In one paragraph

Article in The American journal on addictions, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 37 citations in OpenAlex.

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  14. Prescription Drug Misuse: Taking a Lifespan Perspective.Substance abuse : research and treatment · 2020
    Review
  15. Article
  16. Review
  17. Raising Awareness About Prescription and Stimulant Abuse in College Students Through On-Campus Community Involvement Projects.Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2018
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Timothy E WilensPediatric Psychopharmacology Program, Division of Child Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.ORCID http://orcid.org/0000-0002-5749-8503
Nicholas W CarrellasPediatric Psychopharmacology Program, Division of Child Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.
MaryKate MartelonPediatric Psychopharmacology Program, Division of Child Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.
Amy M YulePediatric Psychopharmacology Program, Division of Child Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.
Ronna FriedPediatric Psychopharmacology Program, Division of Child Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.
Rayce AnselmoDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Sean Esteban McCabeInstitute for Research on Women and Gender, University of Michigan, Ann Arbor, Michigan.
Harvard University · USMassachusetts General Hospital · USInstitute for Women's Policy Research · US

Funding

AACAP Physician Scientist Program in Substance UseK12DA000357 · NIDA · AMERICAN ACADEMY-CHILD/ADOLESCENT PSYCH · PI Kevin M. Gray · 1998 to 2026
$29.1M
Trajectories of Prescription Nonmedical Drug MisuseR01DA031160 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SEAN ESTEBAN MCCABE · 2011 to 2026
$3.7M
Etiologies of Stimulant Misuse in College StudentsK24DA016264 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI WILENS, TIMOTHY E · 2004 to 2013
$1.7M
E-Cigarette Use and Longitudinal Changes in Cigarette Smoking and HealthR01CA203809 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCCABE, SEAN ESTEBAN · 2016 to 2018
$652k
Longitudinal Changes in Recovery from Drug Use Disorders: A National StudyR01DA036541 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCCABE, SEAN ESTEBAN · 2015 to 2017
$647k
NCI NIH HHS R01 CA203809NIDA NIH HHS K12 DA000357NIDA NIH HHS K24 DA016264NIDA NIH HHS R01 DA031160NIDA NIH HHS R01 DA036541
6 · The paper itself

Abstract

BACKGROUND AND

objectivesRelatively little is known about the neuropsychological profiles of college students who misuse prescription stimulant medications.

methodsData presented are from college students aged 18-28 years who misused prescription stimulants prescribed for attention-deficit/hyperactivity disorder and controls (no prescription stimulant misuse). Students were assessed neuropsychologically using the self-report Behavioral Rating Inventory of Executive Functioning (BRIEF-A), the Cambridge Automated Neuropsychological Test and Battery (CANTAB), and other tests of cognitive functioning. The analyses included 198 controls (age 20.7 ± 2.6 years) and 100 prescription stimulant misusers (age 20.7 ± 1.7 years).

resultsOn the BRIEF-A, misusers were more likely than controls to endorse greater dysfunction on 8 of 12 measures including Inhibition, Self Monitor, Initiation, Working Memory, and Plan/Organize, when adjusting for race and sex (all p's < .05). Similarly, when dichotomizing the BRIEF-A as abnormal (T score ≥ 65), misusers had more abnormalities on five of nine subscales, as well as all major indices (p's < .05). Misusers also performed worse on several subtests of the CANTAB and standardized cognitive battery (p's < .05). A proxy of prescription stimulant misuse frequency was positively correlated with greater executive dysfunction on the BRIEF-A. DISCUSSION AND

conclusionsThese data demonstrate elevated risk for neuropsychological dysfunction among students who misuse prescription stimulants compared to non-misusing peers. The presence of ADHD contributed significantly to these cognitive findings. Students who misuse prescription stimulants should be screened for neuropsychological dysfunction. SCIENTIFIC SIGNIFICANCE: These data may better elucidate the neuropsychological profile of college-aged prescription stimulant misusers. (Am J Addict 2017;26:379-387).

Indexed as

Attention Deficit Disorder with HyperactivityCase-Control StudiesCentral Nervous System StimulantsCognitionFemaleHumansMaleNeuropsychological TestsPeer GroupStudentsSubstance-Related DisordersUniversitiesYoung AdultCentral Nervous System Stimulants

Identifiers

PMID28494131
PMCPMC5548389
OpenAlexW2614024334

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.