ArticlePloS one2017
Comparison of spectral-domain optical coherence tomography for intra-retinal layers thickness measurements between healthy and diabetic eyes among Chinese adults.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Assessment of retinal neurodegeneration with spectral-domain optical coherence tomography: a systematic review and meta-analysis.Eye (London, England) · 2021Pooled it
- Choroidal structural and perfusion characteristics across refractive groups in children.Frontiers in medicine · 2026Article
- Peripapillary Bruch's membrane Opening-Minimum Rim Width (BMO-MRW) and microvascular changes in early diabetic retinopathy.BMC ophthalmology · 2025Observational
- Evaluation of thickness of individual macular retinal layers in diabetic eyes from optical coherence tomography.Scientific reports · 2024Article
- Capturing the Transition From Intermediate to Neovascular AMD: Longitudinal Inner Retinal Thinning and Factors Associated With Neuronal Loss.Investigative ophthalmology & visual science · 2023Article
- Imaging biomarkers and clinical factors associated with the rate of progressive inner and outer retinal thinning in patients with diabetic macular edema.Scientific reports · 2023Article
- Mapping the thickness of retinal layers using Spectralis spectral domain optical coherence tomography in Indian eyes.Indian journal of ophthalmology · 2022Article
- Peripapillary vessel density and retinal nerve fiber layer thickness changes in early diabetes retinopathy.International journal of ophthalmology · 2022Article
- Impact of Structural Changes on Multifocal Electroretinography in Patients With Use of Hydroxychloroquine.Investigative ophthalmology & visual science · 2021Article
- Article
- Retinal neurodegeneration in patients with end-stage renal disease assessed by spectral-domain optical coherence tomography.Scientific reports · 2020Observational
- Heritability of Inner Retinal Layer and Outer Retinal Layer Thickness: The Healthy Twin Study.Scientific reports · 2020Article
- The HD-OCT Study May Be Useful in Searching for Markers of Preclinical Stage of Diabetic Retinopathy in Patients with Type 1 Diabetes.Diagnostics (Basel, Switzerland) · 2019Article
- Comment on "The thickness and volume of the choroid, outer retinal layers and retinal pigment epithelium layer changes in patients with diabetic retinopathy".International journal of ophthalmology · 2019Article
- Distinct Retinal Capillary Plexuses in Normal Eyes as Observed in Optical Coherence Tomography Angiography Axial Profile Analysis.Scientific reports · 2018Article
- Macular Inner Retinal Layer Thinning in Diabetic Patients without Retinopathy Measured by Spectral Domain Optical Coherence Tomography.Medical hypothesis, discovery & innovation ophthalmology journal · 2018Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare intra-retinal layer thickness measurements between eyes with no or mild diabetic retinopathy (DR) and age-matched controls using Spectralis spectral-domain optical coherence tomography (SD-OCT).
methodsCross-sectional observational analysis study. High-resolution macular volume scans (30° * 25°) were obtained for 133 type 2 diabetes mellitus (T2DM) patients with no DR, 42 T2DM patients with mild DR and 115 healthy controls. The mean thickness was measured in all 9 Early Treatment Diabetic Retinopathy Study (ETDRS) sectors for 8 separate layers, inner retinal layer (IRL), outer retinal layer (ORL) and total retina (TR), after automated segmentation. The ETDRS grid consisted of three concentric circles of 1-, 3-, and 6-mm diameter. The superior, inferior, temporal, and nasal sectors of the 3- and 6-mm circles were respectively designated as S3, I3, T3, and N3 and S6, I6, T6, and N6. Linear regression analyses were conducted to evaluate the associations between the intra-retinal layer thicknesses, age, diabetes duration, fasting blood glucose and HbA1c.
resultsThe mean age and duration of T2DM were 61.1 and 13.7 years, respectively. Although no significant differences in the average TR and ORL volumes were observed among the groups, significant differences were found in the volume and sectorial thicknesses of the inner plexiform layer (IPL), outer plexiform layer (OPL) and IRL among the groups. In particular, the thicknesses of the IPL (S3, T3, S6, I6 and T6 sectors) and the IRL (S6 sector) were decreased in the no-DR group compared with the controls (P < 0.05). The thickness of the OPL (S3, N3, S6 and N6 sectors) was thinner in the no-DR group than in mild DR (P < 0.05). The average IPL thickness was significantly negatively correlated with age and the duration of diabetes.
conclusionThe assessment of the intra-retinal layer thickness showed a significant decrease in the IPL and IRL thicknesses in Chinese adults with T2DM, even in the absence of visible microvascular signs of DR.
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