SynthesisPloS one2017
The association between vacA or cagA status and eradication outcome of Helicobacter pylori infection: A meta-analysis.
Synthesis in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Clinical relevance of the cagA and vacA s1m1 status and antibiotic resistance in Helicobacter pylori: a systematic review and meta-analysis.BMC infectious diseases · 2022Pooled it
- Real-World Evidence on Different Amoxicillin-Containing Regimens forAntibiotics (Basel, Switzerland) · 2026Article
- Exploring virulence factors of Helicobacter pylori isolated from gastric biopsy.Molecular biology reports · 2024Article
- Study of vacuolating cytotoxin A (vacA) genotypes of ulcerogenic and non-ulcerogenic strains ofSaudi journal of biological sciences · 2023Article
- Article
- Susceptibility patterns and virulence genotypes ofWorld journal of gastroenterology · 2023Article
- A review on the research progress on non-pharmacological therapy ofFrontiers in microbiology · 2023Review
- Comparative Effectiveness of Various Eradication Regimens for Helicobacter Pylori Infection in the Northeastern Region of Poland.International journal of environmental research and public health · 2022Article
- Effect of gastric microbiota on quadrupleWorld journal of gastroenterology · 2021Article
- Review
- Occurrence of cagAScientific reports · 2018Article
- Can bacterial virulence factors predict antibiotic resistantWorld journal of gastroenterology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundH. pylori virulence factors, especially vacA and cagA are important in gastroduodenal disease pathogenesis and affect cure rates. This meta-analysis aimed to clarify the association between vacA or cagA status and eradication outcome of H. pylori infection.
methodsA literature search was performed using electronic databases to identify studies. Twenty-six prospective studies were determined eligible. Meta-analytical techniques were conducted to calculate eradication rates and pooled relative ratios (RR).
resultsThe eradication rate was greater approximately 10% in vacA s1 compared with vacA s2 infected patients, and the pooled RR was 1.164 (95%CI: 1.040-1.303, P = 0.008). A significant association existed between vacA s1 and higher eradication rates in Europe (RR: 1.203, 95%CI: 1.003-1.442, P = 0.046) and Asia (RR: 1.187, 95%CI: 1.028-1.371, P = 0.020), in triple therapy patients (RR: 1.175, 95%CI: 1.012-1.365, P = 0.035). Eradication rates were similar for vacA m1 and m2 genotypes (RR: 0.981, 95%CI: 0.891-1.080, P = 0.690), whereas they were higher by approximately 8% in cagA-positive compared with cagA-negative infected patients, with a pooled RR of 1.094 (95%CI: 1.025-1.168, P = 0.007). A significant association existed between cagA-positive and increased eradication rates in Europe (RR: 1.138, 95%CI: 1.000-1.295, P = 0.049) and Asia (RR: 1.118, 95%CI: 1.051-1.190, P<0.001), in using PCR (RR: 1.232, 95%CI: 1.142-1.329, P<0.001) and protein chips (RR: 1.200, 95%CI: 1.060-1.359, P = 0.004), in triple therapy patients (RR: 1.090, 95%CI: 1.006-1.181, P = 0.034).
conclusionsEvidence indicates that infection with vacA s1, cagA-positive strains, but not vacA s2, cagA-negative, is more conducive to H. pylori eradication.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.