ArticlePloS one2017
NMR quantification of diffusional exchange in cell suspensions with relaxation rate differences between intra and extracellular compartments.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Passive water exchange between multiple sites can explain why apparent exchange rate constants depend on ionic and osmotic conditions in gray matter.Magnetic resonance letters · 2026Article
- Quantifying Transmembrane Water Exchange by Diffusion NMR Methods: From Yeast Cells to Optic Nerve Ex Vivo.NMR in biomedicine · 2026Article
- Passive water exchange between multiple sites can explain why apparent exchange rate constants depend on ionic and osmotic conditions in gray matter.bioRxiv : the preprint server for biology · 2025Article
- LLPS REDIFINE allows the biophysical characterization of multicomponent condensates without tags or labels.Nature communications · 2025Article
- Tuned exchange imaging: Can the filter exchange imaging pulse sequence be adapted for applications with thin slices and restricted diffusion?NMR in biomedicine · 2024Article
- Methods for Oxygen Determination in an NMR Bioreactor as a Surrogate Marker for Metabolomic Studies in Living Cell Cultures.Analytical chemistry · 2023Article
- Repeatability and reproducibility of apparent exchange rate measurements in yeast cell phantoms using filter-exchange imaging.Magma (New York, N.Y.) · 2023Article
- On the sampling strategies and models for measuring diffusion exchange with a double diffusion encoding sequence.Magnetic resonance letters · 2023Article
- Blood-brain barrier water exchange measurements using FEXI: Impact of modeling paradigm and relaxation time effects.Magnetic resonance in medicine · 2023Article
- Filter exchange imaging with crusher gradient modelling detects increased blood-brain barrier water permeability in response to mild lung infection.Fluids and barriers of the CNS · 2023Article
- In vivo methods for imaging blood-brain barrier function and dysfunction.European journal of nuclear medicine and molecular imaging · 2023Review
- Article
- Sensitive, Efficient and Portable Analysis of Molecular Exchange Processes by Hyperpolarized Ultrafast NMR.Angewandte Chemie (International ed. in English) · 2022Article
- Disentangling the effects of restriction and exchange with diffusion exchange spectroscopy.Frontiers in physics · 2022Article
- Gradient waveform design for tensor-valued encoding in diffusion MRI.Journal of neuroscience methods · 2021Review
- Real-time measurement of diffusion exchange rate in biological tissue.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2020Article
- Ultrafast diffusion exchange nuclear magnetic resonance.Nature communications · 2020Article
- Article
- INDIANA: An in-cell diffusion method to characterize the size, abundance and permeability of cells.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2019Article
- Single-channel permeability and glycerol affinity of human aquaglyceroporin AQP3.Biochimica et biophysica acta. Biomembranes · 2019Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Water transport across cell membranes can be measured non-invasively with diffusion NMR. We present a method to quantify the intracellular lifetime of water in cell suspensions with short transverse relaxation times, T2, and also circumvent the confounding effect of different T2 values in the intra- and extracellular compartments. Filter exchange spectroscopy (FEXSY) is specifically sensitive to exchange between compartments with different apparent diffusivities. Our investigation shows that FEXSY could yield significantly biased results if differences in T2 are not accounted for. To mitigate this problem, we propose combining FEXSY with diffusion-relaxation correlation experiment, which can quantify differences in T2 values in compartments with different diffusivities. Our analysis uses a joint constrained fitting of the two datasets and considers the effects of diffusion, relaxation and exchange in both experiments. The method is demonstrated on yeast cells with and without human aquaporins.
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