Evidence map›Paper›PMID 28493912›Full record

Trial reportPloS one2017

Effects of intensity and amount of exercise on measures of insulin and glucose: Analysis of inter-individual variability.

Louise de Lannoy, John Clarke, Paula J Stotz, Robert Ross

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03787836 (Improving Individual Glycemic Response With Exercise Intensity), which is not on this map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03787836 nacompletednot on this mapstarted 2019, after this paper: background citation

Improving Individual Glycemic Response With Exercise Intensity

TypeinterventionalSponsorUniversity of New BrunswickRan2019 to 2021Enrolled61ConditionsPreDiabetes, Diabetes Mellitus, Type 2, Exercise, Physical ActivityArmsMaintained Exercise, Increased Intensity
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Plasma Metabolite Profiles in Response to Chronic Exercise.Medicine and science in sports and exercise · 2018
    Trial
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  7. Review
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  14. Review
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  17. An appraisal of the SDPhysiological reports · 2019
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Louise de LannoySchool of Kinesiology and Health Studies, Queen's University, Kingston, Ontario, Canada.
John ClarkeSchool of Kinesiology and Health Studies, Queen's University, Kingston, Ontario, Canada.
Paula J StotzSchool of Kinesiology and Health Studies, Queen's University, Kingston, Ontario, Canada.
Robert RossSchool of Kinesiology and Health Studies, Queen's University, Kingston, Ontario, Canada.ORCID http://orcid.org/0000-0001-6875-785X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo determine the separate effects of exercise amount and intensity on the rate of response for glucose and insulin variables, where rate of response was defined as the number of individuals with improvement in glucose and insulin values that was beyond the day-to-day variability of measurement.

methodsParticipants were 171 sedentary, middle-aged abdominally obese adults who completed a 24-week intervention. Participants were randomly assigned to (1) no-exercise control (n = 51), (2) low-amount, low-intensity exercise (LALI, n = 38), (3) high-amount, low-intensity exercise (HALI, n = 52), or (4) high-amount, high-intensity exercise (HAHI, n = 30). Two-hour glucose, insulin area under the curve (AUC), and fasting insulin were measured during a 2-hour, 75g oral glucose challenge. The day-to-day variability for these measures was calculated to be ±2.2 mmol/L, ±940.2 pmol/L, and ±38.9 pmol/L, respectively.

resultsAt 24 weeks, the number of nonresponders for 2-hr glucose was 98.0%, 86.8%, 94.2%, 86.7% in the control, LALI, HALI, and HAHI groups, respectively. The number of nonresponders for insulin AUC was 88.0%, 75.7%, 75.0%, 80.0% in the control, LALI, HALI, and HAHI groups, respectively. The number of nonresponders for fasting insulin was 88.2%, 84.2%, 84.6%, 93.3% in the control, LALI, HALI, and HAHI groups, respectively. The rate of response was not different between control and any of the exercise groups for any measure (p>0.05).

conclusionThe improvement in glucose and insulin measures did not exceed the day-to-day variability of measurement for approximately 80% of the participants independent of exercise amount or intensity.

Indexed as

Blood GlucoseBody WeightExerciseExercise TherapyFastingFemaleHumansInsulinMaleMiddle AgedObesity, AbdominalBlood GlucoseInsulin

Identifiers

PMID28493912
PMCPMC5426643

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.