ArticleEuropean journal of pain (London, England)2017
Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR1) gene.
Article in European journal of pain (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Different genes may be involved in distal and local sensitization: A genome-wide gene-based association study and meta-analysis.European journal of pain (London, England) · 2022Pooled it
- Relationship Between Central Sensitization and Genetic Polymorphisms-A Case-Control Study in Fibromyalgia.European journal of pain (London, England) · 2026Trial
- Redox-Related Genetic and Biological Ageing Signals in Rapid Pain Progression of Knee Osteoarthritis: A Hypothesis-Generating Analysis in the Osteoarthritis Initiative.Antioxidants (Basel, Switzerland) · 2026Article
- LOXL2 alleviates post-traumatic knee osteoarthritis and pain.Journal of orthopaedic translation · 2025Article
- Peripheral neuronal sensitization and neurovascular remodelling in osteoarthritis pain.Nature reviews. Rheumatology · 2025Review
- Synovial Fluid Extracellular Vesicles from Patients with Severe Osteoarthritis Differentially Promote a Pro-Catabolic, Inflammatory Chondrocyte Phenotype.Biomolecules · 2025Article
- Skeletal interoception in osteoarthritis.Bone research · 2024Review
- The effects of semaphorin 3A in bone and cartilage metabolism: fundamental mechanism and clinical potential.Frontiers in cell and developmental biology · 2023Review
- Radiological changes in shoulder osteoarthritis and pain sensation correlate with patients' age.Journal of orthopaedic surgery and research · 2022Article
- Osteoarthritis: Novel Molecular Mechanisms Increase Our Understanding of the Disease Pathology.Journal of clinical medicine · 2021Review
- Subchondral bone microenvironment in osteoarthritis and pain.Bone research · 2021Review
- Profiling of inflammatory mediators in the synovial fluid related to pain in knee osteoarthritis.BMC musculoskeletal disorders · 2020Article
- The Role of Substance P in the Regulation of Bone and Cartilage Metabolic Activity.Frontiers in endocrinology · 2020Review
- Neuropeptides: important regulators of joint homeostasis.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2019Review
- Clinical Perspective on Pain and Pain Phenotypes in Osteoarthritis.Current rheumatology reports · 2018Review
- Complex Role of Capsaicin-Sensitive Afferents in the Collagen Antibody-Induced Autoimmune Arthritis of the Mouse.Scientific reports · 2018Article
- Epidemiology of osteoarthritis: literature update.Current opinion in rheumatology · 2018Review
- The Implication of Substance P in the Development of Tendinopathy: A Case Control Study.International journal of molecular sciences · 2017Article
- Mechanisms of Osteoarthritic Pain. Studies in Humans and Experimental Models.Frontiers in molecular neuroscience · 2017Review
Corrections and comments
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Authors and funding
18 authors at 12 institutions in 3 countries.
Funding
Abstract
backgroundSubstance P (SP) is a pain- and inflammation-related neuropeptide which preferentially binds to the neurokinin receptor 1 (NK
methodsParticipants from the Genetics of OA and Lifestyle study were used for the discovery group (n = 1615). Genotype data for six SNPs selected to cover most variation in the TACR1 gene were used to test for an association with symptomatic OA. Replication analysis was performed using data from the Chingford 1000 Women Study, Hertfordshire Cohort Study, Tasmanian Older Adult Cohort Study and the Clearwater OA Study. In total, n = 1715 symptomatic OA and n = 735 asymptomatic OA individuals were analysed.
resultsOut of six SNPs tested in the TACR1 gene, one (rs11688000) showed a nominally significant association with a decreased risk of symptomatic OA in the discovery cohort. This was then replicated in four additional cohorts. After adjusting for age, gender, body mass index and radiographic severity, the G (minor) allele at rs11688000 was associated with a decreased risk of symptomatic OA compared to asymptomatic OA cases (p = 9.90 × 10
conclusionsThis study supports a contribution from the TACR1 gene in human OA pain, supporting further investigation of this gene's function in OA. SIGNIFICANCE: This study contributes to the knowledge of the genetics of painful osteoarthritis, a condition which affects millions of individuals worldwide. Specifically, a contribution from the TACR1 gene to modulating pain sensitivity in osteoarthritis is suggested.
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