ReviewBritish journal of haematology2017
Turf wars: exploring splenomegaly in sickle cell disease in malaria-endemic regions.
Review in British journal of haematology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Persistent Splenomegaly Is Associated with Morbidity in Tanzanian Children with Sickle Cell Anemia: Secondary Analysis of the SPHERE Trial.Acta haematologica · 2026Article
- From early development to maturity: a phenotypic analysis of the Townes sickle cell disease mice.Biology open · 2025Article
- Proteomics-driven screening of artemisinin-based combination ratios and mechanistic insights intoFrontiers in immunology · 2025Article
- Unswitched memory B cell deficiency in children with sickle cell disease and response to pneumococcal polysaccharide vaccine.American journal of hematology · 2024Article
- Exploring the host factors affecting asymptomatic Plasmodium falciparum infection: insights from a rural Burkina Faso study.Malaria journal · 2023Article
- Moderate hypoxia induces metabolic divergence in circulating monocytes and tissue resident macrophages from Berkeley sickle cell anemia mice.Frontiers in medicine · 2023Article
- Prevalence of Splenomegaly and Splenic Complications in Adults with Sickle Cell Disease and Its Relation to Fetal Hemoglobin.International journal of hematology-oncology and stem cell research · 2022Article
- Article
- Splenomegaly in Children and Adolescents.Frontiers in pediatrics · 2021Review
- Sickle cell disease and malaria: decreased exposure and asplenia can modulate the risk from Plasmodium falciparum.Malaria journal · 2020Article
- Consequences ofFrontiers in endocrinology · 2020Article
- Insights into determinants of spleen injury in sickle cell anemia.Blood advances · 2019Article
- Sickle Cell Disease-Genetics, Pathophysiology, Clinical Presentation and Treatment.International journal of neonatal screening · 2019Review
- HAEMATOLOGICAL PROFILE AND BLOOD TRANSFUSION PATTERN OF PATIENTS WITH SICKLE CELL ANAEMIA VARY WITH SPLEEN SIZE.Annals of Ibadan postgraduate medicine · 2019Article
- Prescription audit in a paediatric sickle cell clinic in South-West Nigeria: A cross-sectional retrospective study.Malawi medical journal : the journal of Medical Association of Malawi · 2017Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Sickle cell disease (SCD) is a group of recessively inherited disorders of erythrocyte function that presents an ongoing threat to reducing childhood and adult morbidity and mortality around the world. While decades of research have led to improved survival for SCD patients in wealthy countries, survival remains dismal in low- and middle-income countries. Much of the early mortality associated with SCD is attributed to increased risk of infections due to early loss of splenic function. In the West, bacterial infections with encapsulated organisms are a primary concern. In sub-Saharan Africa, where the majority of infants with SCD are born, the same is true. However malaria presents an additional threat to survival. The search for factors that define variability in sickle cell phenotypes should include environmental modifiers, such as malaria. Further exploration of this relationship could lead to novel strategies to reduce morbidity and mortality attributable to infections. In this review, we explore the interactions between SCD, malaria and the spleen to better understand how splenomegaly and splenic (dys)function may co-exist in patients with SCD living in malaria-endemic areas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.