Evidence map›Paper›PMID 28493366›Full record

ArticleThe Journal of pathology2017

Frequent IDH2 R172 mutations in undifferentiated and poorly-differentiated sinonasal carcinomas.

Snjezana Dogan, Deborah J Chute, Bin Xu, Ryan N Ptashkin, Raghu Chandramohan, Jacklyn Casanova-Murphy, Khedoudja Nafa, Justin A Bishop, Simion I Chiosea, Edward B Stelow and 5 more

Open access · greenAbstract read
In one paragraph

Article in The Journal of pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 110 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Clinical, genetic and immunohistochemical characterization of sinonasal tumors with neuroectodermal differentiation.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  5. Review
  6. Review
  7. Article
  8. Analysis of ASCL1/NEUROD1/POU2F3/YAP1 Yields Novel Insights for the Diagnosis of Olfactory Neuroblastoma and Identifies Sinonasal Tuft Cell-Like Carcinoma.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2025
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Molecular pathology in diagnosis and prognostication of head and neck tumors.Virchows Archiv : an international journal of pathology · 2024
    Review
  16. Article
  17. Article
  18. Review
  19. Molecular Evidence for Olfactory Neuroblastoma as a Tumor of Malignant Globose Basal Cells.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Snjezana DoganDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-4905-8946
Deborah J ChuteDepartment of Pathology, Cleveland Clinic, Cleveland, OH, USA.
Bin XuDepartment of Pathology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Ryan N PtashkinDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Raghu ChandramohanDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Jacklyn Casanova-MurphyDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Khedoudja NafaDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Justin A BishopDepartment of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA.
Simion I ChioseaDepartment of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Edward B StelowDepartment of Pathology, University of Virginia Health System, Charlottesville, VA, USA.
Ian GanlyDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
David G PfisterDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Nora KatabiDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ronald A GhosseinDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Michael F BergerDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Memorial Sloan Kettering Cancer Center · USCleveland Clinic · USJohns Hopkins Hospital · USSunnybrook Health Science Centre · CAUniversity of Pittsburgh Medical Center · USUniversity of Virginia Health System · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Sinonasal undifferentiated carcinoma (SNUC) is a high-grade malignancy with limited treatment options and poor outcome. A morphological spectrum of 47 sinonasal tumours including 17 (36.2%) SNUCs was analysed at genomic level. Thirty carcinomas (cohort 1) were subjected to a hybridization exon-capture next-generation sequencing assay (MSK-IMPACT

Indexed as

MutationAdultAgedAged, 80 and overBiomarkers, TumorCarcinomaCarcinoma, NeuroendocrineCarcinoma, Small CellDNA Mutational AnalysisFemaleGene DeletionGenes, p53High-Throughput Nucleotide SequencingHumansIsocitrate DehydrogenaseMaleBiomarkers, TumorIDH2 protein, humanIsocitrate DehydrogenaseSMARCB1 ProteinSMARCB1 protein, humanIDH2 R172sinonasal undifferentiated carcinomaSNUC

Identifiers

PMID28493366
PMCPMC5639875
OpenAlexW2613321519

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.