ArticleBritish journal of pharmacology2017
Response of Htr3a knockout mice to antidepressant treatment and chronic stress.
Article in British journal of pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Boldine Mitigates Chronic Unpredictable Stress-Induced Depression by Suppressing Serotonin 3A Receptor-Calcium/Calmodulin-Dependent Protein Kinase II Signaling and Nucleotide-Binding Domain Leucine-Rich Repeat Protein 3 Inflammasome in the Hippocampus.ACS pharmacology & translational science · 2026Article
- Expression Profiles of Genes Related to Serotonergic Synaptic Function in Hypothalamus of Hypertensive and Normotensive Rats in Basal and Stressful Conditions.International journal of molecular sciences · 2025Article
- Article
- Phytoconstituents Targeting the Serotonin 5-HTACS pharmacology & translational science · 2024Review
- Serotonin limits generation of chromaffin cells during adrenal organ development.Nature communications · 2022Article
- DNA-methylation dynamics across short-term, exposure-containing CBT in patients with panic disorder.Translational psychiatry · 2022Article
- Analysis of the Underlying Mechanism of the Jiu Wei Zhen Xin Formula for Treating Generalized Anxiety Disorder Based on Network Pharmacology of Traditional Chinese Medicine.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- NLRP3/caspase-1/GSDMD-mediated pyroptosis exerts a crucial role in astrocyte pathological injury in mouse model of depression.JCI insight · 2021Article
- 5-HT Receptors and the Development of New Antidepressants.International journal of molecular sciences · 2021Review
- Candidate Strategies for Development of a Rapid-Acting Antidepressant Class That Does Not Result in Neuropsychiatric Adverse Effects: Prevention of Ketamine-Induced Neuropsychiatric Adverse Reactions.International journal of molecular sciences · 2020Review
- Key role of the 5-HT1A receptor addressing protein Yif1B in serotonin neurotransmission and SSRI treatment.Journal of psychiatry & neuroscience : JPN · 2020Article
- Interaction between Mesocortical and Mesothalamic Catecholaminergic Transmissions Associated with NMDA Receptor in the Locus Coeruleus.Biomolecules · 2020Article
- Vortioxetine Subchronically Activates Serotonergic Transmission via Desensitization of Serotonin 5-HTInternational journal of molecular sciences · 2019Article
- Single-cell RNA-Seq characterization of anatomically identified OLM interneurons in different transgenic mouse lines.The European journal of neuroscience · 2019Article
- Pharmacological Discrimination of Effects of MK801 on Thalamocortical, Mesothalamic, and Mesocortical Transmissions.Biomolecules · 2019Article
- Distribution of Caskin1 protein and phenotypic characterization of its knockout mice using a comprehensive behavioral test battery.Molecular brain · 2018Article
- Response of Htr3a knockout mice to antidepressant treatment and chronic stress.British journal of pharmacology · 2017Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeIt has recently been suggested that 5-HT EXPERIMENTAL APPROACH: To further explore this hypothesis, we used mice lacking the 5-HT KEY
resultsIn basal conditions, Htr3a KO mice displayed anxiolytic- and antidepressant-like behaviours in the elevated plus maze, the social interaction and the forced swim tests (FST), but behaved as WT mice in response to acute citalopram in the FST. However, the effects of fluoxetine were blunted in Htr3a KO mice in these same tests. In an in vitro electrophysiological paradigm, a low-dose citalopram treatment triggered 5-HT CONCLUSIONS AND IMPLICATIONS: Taken together, these data show that Htr3a deletion promotes SSRI efficacy and prevents the occurrence of stress-induced deleterious effects, suggesting that the 5-HT
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.